Derleme
BibTex RIS Kaynak Göster

“Euterpe Olerecea” nın Antioksidan ve Öğrenme –Bellek Üzerindeki Etkileri

Yıl 2018, Cilt: 40 Sayı: 1, 116 - 120, 31.01.2018
https://doi.org/10.20515/otd.304318

Öz

Öğrenme ve bellek bozuklukları; yaşam kalitesini olumsuz yönde
etkileyen birçok hastalıkla primer veya sekonder olarak ilişkilidir. Öğrenme ve
bellek, çevreden gelen uyaranların değerlendirilmesi ve uygun davranışların
geliştirilmesi gibi temel zihinsel süreçleri düzenler. İnsanlar
gerçekleştirdikleri her işlemde bilinçli veya bilinçsiz olarak bellek
işlevlerine başvururlar. Kognitif bozukluklar başta demans ve Alzheimer
hastalığı olmak üzere; şizofreni, depresyon, anksiyete, uyku bozuklukları,
dikkat eksikliği ve hiperaktivite, madde bağımlılığı gibi birçok durumla
ilişkilendirilmektedir. Alzheimer hastalığının erken dönemlerinde ortaya çıkan
kognitif bozulmalar, episodik bellek ve uzamsal oryantasyon yeteneğinde
gerileme ile başlar.



Dünya Sağlık Örgütü verilerine göre Alzheimer hastalığı dünya çapında
47. 5 milyon kişi etkilemişken her yıl bu sayıya 7. 7 milyon yeni vaka
eklenmektedir. Son yıllarda çok sayıda çalışmada, Açai bitkisi ekstraktı olarak
da bilinen Euterpe olerecea’nın Parkinson ve Alzheimer gibi nörodejeneratif
hastalıkların riskini azalttığı, serebral kortekste %48 civarında, hipokampusta
yaklaşık %64 ve serebellumda yaklaşık %72 olmak üzere nöroprotektif etki  ve 
beyin hücrelerinde oluşan inflamasyon ve oksidatif hasarın
azaltılmasında başarı sağladığı gösterilmiştir.

Kaynakça

  • 1. Yamaguchi, K.K., Pereira, L.F., Lamarão, C.V, Lima, E.S. , Veiga Junior, V.F. (2015). Amazon acai : chemistry and biological activities: a review. Food Chemistry 179: 137-151.
  • 2. Cesar, LT.,de Freitas Cabral, M., Maia,GA., de Figueiredo , RW., de Miranda, MR.et al.(2014). Effects of clarification on physicochemical characteristics, antioxidant capacity and quality attributes of açai (Euterpe oleracea Mart.) juice. Journal Food Science Technology. 51(11),3293-300.
  • 3. Xie, C., Kang, J., Li, Z., Schauss, A.G., Badger, T.M., Nagarajan, S., Wu, T., Wu, X.(2012).The açaí flavonoid velutin is a potent anti-inflammatory agent: blockade of LPS-mediated TNF-&#945 ;and IL-6 production through inhibiting NF-κ; B activation and MAPK pathway. Journal of Nutritional Biochemistry, 23(9),1184-91.
  • 4. Moura, RS., Ferreira, TS., Lopes, AA., Pires, KM., Nesi, RT., Resende, AC., Souza, PJ.,Silva,AJ.,Borges,RM.,Porto,LC.,Valenca,SS.(2012).Effects of Euterpe oleracea Mart. (AÇAÍ) extract in acute lung inflammation induced by cigarette smoke in themouse. Phytomedicine,(3-4),262-9.
  • 5. Dias, MM., Noratto, G., Martino, HS., Arbizu , S., Peluzio Mdo, C.,Talcott, S.,Ramos, AM.,Mertens-Talcott, SU.(2014). Pro-apoptotic activities of polyphenolics from açai (Euterpe oleracea Martius)in human SW-480 colon cancercells. Nutrional Cancer,66(8),1394-405.
  • 6. Silva, DF.,Vidal, FC.,Santos,D.,Costa, MC.,Morgado-Díaz, JA.,Desterro Soares BrandãoNascimento, M.,de Moura,RS. (2014).Cytotoxic effects of Euterpe oleracea Mart. in malignant cell lines. BMC Complement Altern Med.14-175.
  • 7. Fragoso,MF., Romualdo,GR.,Ribeiro,DA., Barbisan, LF.(2013). Açai (Euterpe oleracea Mart.) feeding attenuates dimethylhydrazine-induced rat colon carcinogenesis. Food Chemistry Toxicol, (58)68-76
  • 8. Fragoso, MF., Prado, MG., Barbosa, L., Rocha, NS.,Barbisan, LF. (2012). Inhibition of mouse urinary bladder carcinogenesis by açai fruit (Euterpe oleraceae Martius)intake. Plant Foods Human Nutrional,67(3),235-41.
  • 9. Zapata-Sudo,G.,Silva,JS.,Pereira, SL., Souza,PJ.,Moura,RS., Sudo,RT. (2014). Oral treatment with Euterpe oleracea Mart. (açaí) extract improves cardiac dysfunction and exercise intolerance in rats subjected to myocardial infarction.BMC complementary and alternative medicine , 8;14:227.
  • 10. Silva Santos, V., Almeida Teixeira, GH., Barbosa,F.,Jr. (2014). Açaí (Euterpe oleracea Mart.):a tropical fruit with high levels of essential minerals-especially manganese-andits contribution as a source of natural mineral supplementation. J Toxicol Environ Health A.(1-3):80-9.
  • 11. Wong, DY.,Musgrave, IF.,Harvey, BS., Smid SD.(2013).Açaí (Euterpe oleraceae Mart.) berry extract exerts neuroprotective effects against-amyloid exposure in vitro. Neuroscience letters, (556),221-6.
  • 12. Spada,PD.,Dani,C.,Bortolini,GV., Funchal,C.,Henriques,JA.,Salvador,M. (2009). Frozen fruit pulp of Euterpe oleraceae Mart. (Acai) prevents hydrogen peroxide-induced damage in the cerebral cortex, cerebellum, and hippocampus of rats. Journal of Medical Food,(5):1084-8).
  • 13. Pozo-Insfran, D., Percival, SS.,Talcott, ST. (2006). Açai (Euterpe oleracea Mart.) polyphenolics in their glycoside and aglycone forms induce apoptosis of HL-60 leukemiacells. JAgricFoodChemistry,1222-9.
  • 14. Çorumlu E.P., Aydın O.Ö., Aydın E.G., Ulupınar,E. (2015). Effects of single-dose ketamine infusion on behavioral parametres and neuronal activation in the medial prefrontal cortex of juvenile rats exposed to prenatal stress. Anatomy.
  • 15. Soztutara,E.,Çolak,E.,Ulupınar,E. (2015). Gender-and anxiety level-dependent effects of perinatal stress exposure on medial prefrontal cortex. Elsevier. (2),274-84.
  • 16. Karabeg,MM., Grauthoff,S., Kollert,SY., Weidner,M., Heiming,RS., Jansen, F., Popp, S., Kaiser, S., Lesch, KP., Sachser, N., Schmitt, A G., Lewejohann,L. (2013). 3,4,5-HTT Deficiency Affects Neuroplasticity and Increases Stress Sensitivity Resulting in Altered Spatial Learning Performance in the Morris Water Maze but Not in the Barnes Maze. PLos One,8(10).
  • 17. Spada, PD1., Dani, C., Bortolini, GV., Funchal, C., Henriques, JA., Salvador, M., Frozen,(2009).Fruit pulp of Euterpe oleraceae Mart. (Acai) prevents hydrogen peroxide-induced damage in the cerebral cortex,cerebellum, and hippocampus of rats. Journal of Medical Food,12(5):1084-8.
  • 18. Wong,DY., Musgrave,IF., Harvey, BS., Smid,SD.(2013).Açaí (Euterpe oleracea Mart.)berry extract exerts neuroprotective effects against β-amyloid exposure in vitro.Neuroscience letters,27;556:221-6.
  • 19. Zapata-Sudo, G., da Silva, JS., Pereira, SL., Souza, PJ., de Moura, RS., Sudo, RT.(2014).Oral treatment with Euterpe oleracea Mart.(açaí) extract improves cardiac dysfunction and exercise intolerance in rats subjected to myocardial infarction. BMC complementary and alternative medicine, 14-227.
  • 20. Cesar,LT., Freitas Cabral, M., Maia, GA., deFigueiredo,RW., deMiranda, MR., deSousa,PH., Brasil,IM., Gomes,CL.(2012).Effects of clarification on physicochemical characteristics, antioxidant capacity and quality attributes of açaí (Euterpe oleracea Mart.) juice. Advance journal of food science and technology,51(11):3293-300.

The Effects of Euterpe Olerecea on Learning and Memory and Antioxidant Parameters

Yıl 2018, Cilt: 40 Sayı: 1, 116 - 120, 31.01.2018
https://doi.org/10.20515/otd.304318

Öz

Learning and memory disorders are associated primarily or
secondarily with  many diseases that
adversely  affect the  quality of life.  Learning and memory regulates main cognitive
processes evaluating stimulus from environmental and improving suitable
behaviours. People consciously or unconsciously apply to memory functions in all
processes they performed. Cognitive disorders are associated with mainly
dementia and Alzheimer’s disease, and also with many conditions such as
schizophrenia, depression, anxiety, insomnia, attention deficit and
hyperactivity disorder. Cognitive disorders which arise at early stages of
Alzheimer’s disease introduce as 
regression in the episodic memory and spatial orientation skills.
According to the data of World Health Organization ; 47.5 million people have
dementia worldwide and 7.7 million new cases ocur every year. Some studies show
that Euterpe olerecea, known as extract of Açai plant, decreases the risk of
neurodejenerative diseases such as Parkinson’s disease and Alzheimer’s disease,
exerted neuroprotective effects on cerebral cortex around 48%, hippocampus
about 64%, and cerebellum about 72% and 
was reported to be successful at reducing inflammation and oxidative
damage in brain. 

Kaynakça

  • 1. Yamaguchi, K.K., Pereira, L.F., Lamarão, C.V, Lima, E.S. , Veiga Junior, V.F. (2015). Amazon acai : chemistry and biological activities: a review. Food Chemistry 179: 137-151.
  • 2. Cesar, LT.,de Freitas Cabral, M., Maia,GA., de Figueiredo , RW., de Miranda, MR.et al.(2014). Effects of clarification on physicochemical characteristics, antioxidant capacity and quality attributes of açai (Euterpe oleracea Mart.) juice. Journal Food Science Technology. 51(11),3293-300.
  • 3. Xie, C., Kang, J., Li, Z., Schauss, A.G., Badger, T.M., Nagarajan, S., Wu, T., Wu, X.(2012).The açaí flavonoid velutin is a potent anti-inflammatory agent: blockade of LPS-mediated TNF-&#945 ;and IL-6 production through inhibiting NF-κ; B activation and MAPK pathway. Journal of Nutritional Biochemistry, 23(9),1184-91.
  • 4. Moura, RS., Ferreira, TS., Lopes, AA., Pires, KM., Nesi, RT., Resende, AC., Souza, PJ.,Silva,AJ.,Borges,RM.,Porto,LC.,Valenca,SS.(2012).Effects of Euterpe oleracea Mart. (AÇAÍ) extract in acute lung inflammation induced by cigarette smoke in themouse. Phytomedicine,(3-4),262-9.
  • 5. Dias, MM., Noratto, G., Martino, HS., Arbizu , S., Peluzio Mdo, C.,Talcott, S.,Ramos, AM.,Mertens-Talcott, SU.(2014). Pro-apoptotic activities of polyphenolics from açai (Euterpe oleracea Martius)in human SW-480 colon cancercells. Nutrional Cancer,66(8),1394-405.
  • 6. Silva, DF.,Vidal, FC.,Santos,D.,Costa, MC.,Morgado-Díaz, JA.,Desterro Soares BrandãoNascimento, M.,de Moura,RS. (2014).Cytotoxic effects of Euterpe oleracea Mart. in malignant cell lines. BMC Complement Altern Med.14-175.
  • 7. Fragoso,MF., Romualdo,GR.,Ribeiro,DA., Barbisan, LF.(2013). Açai (Euterpe oleracea Mart.) feeding attenuates dimethylhydrazine-induced rat colon carcinogenesis. Food Chemistry Toxicol, (58)68-76
  • 8. Fragoso, MF., Prado, MG., Barbosa, L., Rocha, NS.,Barbisan, LF. (2012). Inhibition of mouse urinary bladder carcinogenesis by açai fruit (Euterpe oleraceae Martius)intake. Plant Foods Human Nutrional,67(3),235-41.
  • 9. Zapata-Sudo,G.,Silva,JS.,Pereira, SL., Souza,PJ.,Moura,RS., Sudo,RT. (2014). Oral treatment with Euterpe oleracea Mart. (açaí) extract improves cardiac dysfunction and exercise intolerance in rats subjected to myocardial infarction.BMC complementary and alternative medicine , 8;14:227.
  • 10. Silva Santos, V., Almeida Teixeira, GH., Barbosa,F.,Jr. (2014). Açaí (Euterpe oleracea Mart.):a tropical fruit with high levels of essential minerals-especially manganese-andits contribution as a source of natural mineral supplementation. J Toxicol Environ Health A.(1-3):80-9.
  • 11. Wong, DY.,Musgrave, IF.,Harvey, BS., Smid SD.(2013).Açaí (Euterpe oleraceae Mart.) berry extract exerts neuroprotective effects against-amyloid exposure in vitro. Neuroscience letters, (556),221-6.
  • 12. Spada,PD.,Dani,C.,Bortolini,GV., Funchal,C.,Henriques,JA.,Salvador,M. (2009). Frozen fruit pulp of Euterpe oleraceae Mart. (Acai) prevents hydrogen peroxide-induced damage in the cerebral cortex, cerebellum, and hippocampus of rats. Journal of Medical Food,(5):1084-8).
  • 13. Pozo-Insfran, D., Percival, SS.,Talcott, ST. (2006). Açai (Euterpe oleracea Mart.) polyphenolics in their glycoside and aglycone forms induce apoptosis of HL-60 leukemiacells. JAgricFoodChemistry,1222-9.
  • 14. Çorumlu E.P., Aydın O.Ö., Aydın E.G., Ulupınar,E. (2015). Effects of single-dose ketamine infusion on behavioral parametres and neuronal activation in the medial prefrontal cortex of juvenile rats exposed to prenatal stress. Anatomy.
  • 15. Soztutara,E.,Çolak,E.,Ulupınar,E. (2015). Gender-and anxiety level-dependent effects of perinatal stress exposure on medial prefrontal cortex. Elsevier. (2),274-84.
  • 16. Karabeg,MM., Grauthoff,S., Kollert,SY., Weidner,M., Heiming,RS., Jansen, F., Popp, S., Kaiser, S., Lesch, KP., Sachser, N., Schmitt, A G., Lewejohann,L. (2013). 3,4,5-HTT Deficiency Affects Neuroplasticity and Increases Stress Sensitivity Resulting in Altered Spatial Learning Performance in the Morris Water Maze but Not in the Barnes Maze. PLos One,8(10).
  • 17. Spada, PD1., Dani, C., Bortolini, GV., Funchal, C., Henriques, JA., Salvador, M., Frozen,(2009).Fruit pulp of Euterpe oleraceae Mart. (Acai) prevents hydrogen peroxide-induced damage in the cerebral cortex,cerebellum, and hippocampus of rats. Journal of Medical Food,12(5):1084-8.
  • 18. Wong,DY., Musgrave,IF., Harvey, BS., Smid,SD.(2013).Açaí (Euterpe oleracea Mart.)berry extract exerts neuroprotective effects against β-amyloid exposure in vitro.Neuroscience letters,27;556:221-6.
  • 19. Zapata-Sudo, G., da Silva, JS., Pereira, SL., Souza, PJ., de Moura, RS., Sudo, RT.(2014).Oral treatment with Euterpe oleracea Mart.(açaí) extract improves cardiac dysfunction and exercise intolerance in rats subjected to myocardial infarction. BMC complementary and alternative medicine, 14-227.
  • 20. Cesar,LT., Freitas Cabral, M., Maia, GA., deFigueiredo,RW., deMiranda, MR., deSousa,PH., Brasil,IM., Gomes,CL.(2012).Effects of clarification on physicochemical characteristics, antioxidant capacity and quality attributes of açaí (Euterpe oleracea Mart.) juice. Advance journal of food science and technology,51(11):3293-300.
Toplam 20 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Sağlık Kurumları Yönetimi
Bölüm DERLEMELER / REVIEWS
Yazarlar

Fatma Sultan Kılıç

Şule Aydın

Cafer Yıldırım Bu kişi benim

Yayımlanma Tarihi 31 Ocak 2018
Yayımlandığı Sayı Yıl 2018 Cilt: 40 Sayı: 1

Kaynak Göster

Vancouver Kılıç FS, Aydın Ş, Yıldırım C. “Euterpe Olerecea” nın Antioksidan ve Öğrenme –Bellek Üzerindeki Etkileri. Osmangazi Tıp Dergisi. 2018;40(1):116-20.


13299        13308       13306       13305    13307  1330126978