Araştırma Makalesi
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Yıl 2019, Cilt: 5 Sayı: 2, 65 - 73, 20.06.2019

Öz

Kaynakça

  • REFERENCES 1. Ryan CM, Bradley TD (2005) Pathogenesis of obstructive sleep apnea. J Appl Physiol (1985) 99: 2440–2450 http://dx.doi.org/10.1378/chest.127.2.536 2. Bilgin C, Erkorkmaz U, Ucar MK, Akin N, Nalbant A, Annakkaya AN. Use of a portable monitoring device (Somnocheck Micro) for the investigation and diagnosis of obstructive sleep apnoea in comparison with polysomnography. Pak J Med Sci. 2016;32(2):471-475. doi: http://dx.doi.org/10.12669/pjms.322.9561 3. Young T, Patla M, Dempsey J, Weber S, Badr S. The occurrence of sleep disordered breathing among middle aged adults. N. England J. Med. 1993; 328: 1230-1235. http://dx.doi.org/10.1056/NEJM19930429328170. 4. Köktürk O, Obstructive sleep apnea syndrome: epidemiology, Tuberk Toraks 1998; 46(2):193-201(In Turkish). 5. Martinez D, Klein C, Rahmeier L, da Silva RP, Fiori CZ, Cassol CM et al. Sleep apnea is a stronger predictor for coronary heart disease than traditional risk factors. Sleep Breath. 2012; 16: 695–701. http://dx.doi.org/10.1007/s11325-011-0559-0 6. Peker Y, Hedner J, Norum J, Kraiczi H, Carlson J. Increased incidence of cardiovascular disease in middle-aged men with obstructive sleep apnea: a 7year follow up. Am J Respir Crit Care Med 2002;166:159-165. http://dx.doi.org/10.1164/rccm.2105124. 7. Li H, Gong Q, Shao J, Liu X, Zhao Y. Cognitive dysfunction in type 2 diabetes patients accompanied with obstructive sleep apnea syndrome. Pak J Med Sci 2014;30(6):1388-1392. http://dx.doi.org/10.12669/pjms.306.5861 8. Silvestrini M, Rizzato B, Placidi F, Baruffaldi R, Bianconi A, Diomedi M. Carotid artery wall thickness in patients with obstructive sleep apnea syndrome. Stroke 2002;33:1782-1785. 9. Gourgou S, Dedieu F, Sancho-Garnier H. Lower limb venous insufficiency and tobacco smoking: a casecontrol study. Am J Epidemiol 2002;155:1007. 10. Arbak P, Yavuz O, Bukan N, Balbay O, Ulger F, Annakkaya AN. Serum Oxidant and Antioxidant Levels in Diesel Exposed Toll Collectors. J Occup Health 2004; 46: 281–288. 11. Lorenz M. Prediction of clinical cardiovascular events with carotid intima media thickness. A systematic review and meta-analysis.” Circulation 2007; 115;459-467. 12. Touboul PJ, Elbaz A, Koller C, Lucas C, Adraï V, Chédru F et al. Common carotid artery intima-media thickness and brain infarction: the Etude du Profil Genetique de l’Infarctus Cerebral (GENIC) casecontrol study. The GENIC Investigators. Circulation 2000;102:313-318. 13. Celik A, Ozcetin M, Celikyay ZR, Sogut E, Yerli Y, Kadi H et al. Evaluation of possible subclinical atherosclerosis in adolescents with a family history of premature atherosclerosis. Atherosclerosis. 2012 Jun;222(2):537-540 http://dx.doi.org/10.1016/j.atherosclerosis.2012.03.02 6 14. Niu X, Chen X, Xiao Y, Dong J, Zhang R, Lu M, Kong W. The Differences in Homocysteine Level between Obstructive Sleep Apnea Patients and Controls: A Meta-Analysis. PLoS One. 2014; 9(4): e95794. http://dx.doi.org/10.1371/journal.pone.0095794 15. Minoguchi K, Yokoe T, Tazaki T, Minoguchi H, Tanaka A, Oda N et al. Increased carotid intimamedia thickness and serum inflammatory markers in obstructive sleep apnea. Am J Respir Crit Care Med. 2005 Sep 1;172(5):625-630 http://dx.doi.org/10.1164/rccm.200412-1652OC 16. Misailidi M , Tzatzarakis MN , Kavvalakis MP , Koutedakis Y , Tsatsakis AM , Flouris AD . Instruments to assess secondhand smoke exposure in large cohorts of never smokers: the smoke scales . PLoS ONE. 2014 ; 9 ( 1 ): e85809 . http://dx.doi.org/10.1371/journal.pone.0085809 17. Nadeem R, Singh M, Nida M, Waheed I, Khan A, Ahmed S et al. Effect of Obstructive Sleep Apnea Hypopnea Syndrome on Lipid Profile: A MetaRegression Analysis. J Clin Sleep Med. 2014 May 15; 10(5): 475–489. http://dx.doi.org/10.5664/jcsm.3690 18. Gunbatar H, Sertogullarindan B, Ekin S, Akdag S, Arisoy A, Sayhan H. The Correlation between Red Blood Cell Distribution Width Levels with the Severity of Obstructive Sleep Apnea and Carotid Intima Media Thickness Med Sci Monit. 2014; 20: 2199–2204. doi: 10.12659/MSM.891001

Carotid Intima-Media Thickness in Patients with Obstructive Sleep Apnoea Syndrome

Yıl 2019, Cilt: 5 Sayı: 2, 65 - 73, 20.06.2019

Öz

Objective: This study was performed retrospectively to evaluate the relationship between smoking, weight, biochemical, and hematological parameters and Common Carotid Artery- Intima Media Thickness (CCA-IMT) in patients with obstructive sleep apnoea syndrome (OSAS).  Methods: 96 OSAS patients aged between 30 and 76 years (Average = 47 ±12), and 48 control subjects aged between 22 and 75 years (Average = 53 ±11) were evaluated. Doppler ultrasonography was used to measure CCA-IMT of subjects, grouped based on Apnoea hypopnea index (AHI), smoking habit, and body mass index (BMI). Results: It is observed that CCA- IMT increases in OSAS patients. The hemoglobin and hematocrit 
values were significantly different in the OSAS group against the controls. This can be attributed to an increase in erythrocyte due to hypoxia. The levels of triglyceride, CRP, and homocysteine were found to be higher in patients than in controls, though not statistically significant.  Conclusions: Sleep apnoea-related hypoxia has hazardous effects on human health. Hypoxia and apnoea that constitutes an important percentage of disordered breathing events seem to contribute heavily to an increase in IMT. Additionally, CCAIMT is highly related to smoking; yet even in nonsmokers, OSAS is an independent risk factor. 

Kaynakça

  • REFERENCES 1. Ryan CM, Bradley TD (2005) Pathogenesis of obstructive sleep apnea. J Appl Physiol (1985) 99: 2440–2450 http://dx.doi.org/10.1378/chest.127.2.536 2. Bilgin C, Erkorkmaz U, Ucar MK, Akin N, Nalbant A, Annakkaya AN. Use of a portable monitoring device (Somnocheck Micro) for the investigation and diagnosis of obstructive sleep apnoea in comparison with polysomnography. Pak J Med Sci. 2016;32(2):471-475. doi: http://dx.doi.org/10.12669/pjms.322.9561 3. Young T, Patla M, Dempsey J, Weber S, Badr S. The occurrence of sleep disordered breathing among middle aged adults. N. England J. Med. 1993; 328: 1230-1235. http://dx.doi.org/10.1056/NEJM19930429328170. 4. Köktürk O, Obstructive sleep apnea syndrome: epidemiology, Tuberk Toraks 1998; 46(2):193-201(In Turkish). 5. Martinez D, Klein C, Rahmeier L, da Silva RP, Fiori CZ, Cassol CM et al. Sleep apnea is a stronger predictor for coronary heart disease than traditional risk factors. Sleep Breath. 2012; 16: 695–701. http://dx.doi.org/10.1007/s11325-011-0559-0 6. Peker Y, Hedner J, Norum J, Kraiczi H, Carlson J. Increased incidence of cardiovascular disease in middle-aged men with obstructive sleep apnea: a 7year follow up. Am J Respir Crit Care Med 2002;166:159-165. http://dx.doi.org/10.1164/rccm.2105124. 7. Li H, Gong Q, Shao J, Liu X, Zhao Y. Cognitive dysfunction in type 2 diabetes patients accompanied with obstructive sleep apnea syndrome. Pak J Med Sci 2014;30(6):1388-1392. http://dx.doi.org/10.12669/pjms.306.5861 8. Silvestrini M, Rizzato B, Placidi F, Baruffaldi R, Bianconi A, Diomedi M. Carotid artery wall thickness in patients with obstructive sleep apnea syndrome. Stroke 2002;33:1782-1785. 9. Gourgou S, Dedieu F, Sancho-Garnier H. Lower limb venous insufficiency and tobacco smoking: a casecontrol study. Am J Epidemiol 2002;155:1007. 10. Arbak P, Yavuz O, Bukan N, Balbay O, Ulger F, Annakkaya AN. Serum Oxidant and Antioxidant Levels in Diesel Exposed Toll Collectors. J Occup Health 2004; 46: 281–288. 11. Lorenz M. Prediction of clinical cardiovascular events with carotid intima media thickness. A systematic review and meta-analysis.” Circulation 2007; 115;459-467. 12. Touboul PJ, Elbaz A, Koller C, Lucas C, Adraï V, Chédru F et al. Common carotid artery intima-media thickness and brain infarction: the Etude du Profil Genetique de l’Infarctus Cerebral (GENIC) casecontrol study. The GENIC Investigators. Circulation 2000;102:313-318. 13. Celik A, Ozcetin M, Celikyay ZR, Sogut E, Yerli Y, Kadi H et al. Evaluation of possible subclinical atherosclerosis in adolescents with a family history of premature atherosclerosis. Atherosclerosis. 2012 Jun;222(2):537-540 http://dx.doi.org/10.1016/j.atherosclerosis.2012.03.02 6 14. Niu X, Chen X, Xiao Y, Dong J, Zhang R, Lu M, Kong W. The Differences in Homocysteine Level between Obstructive Sleep Apnea Patients and Controls: A Meta-Analysis. PLoS One. 2014; 9(4): e95794. http://dx.doi.org/10.1371/journal.pone.0095794 15. Minoguchi K, Yokoe T, Tazaki T, Minoguchi H, Tanaka A, Oda N et al. Increased carotid intimamedia thickness and serum inflammatory markers in obstructive sleep apnea. Am J Respir Crit Care Med. 2005 Sep 1;172(5):625-630 http://dx.doi.org/10.1164/rccm.200412-1652OC 16. Misailidi M , Tzatzarakis MN , Kavvalakis MP , Koutedakis Y , Tsatsakis AM , Flouris AD . Instruments to assess secondhand smoke exposure in large cohorts of never smokers: the smoke scales . PLoS ONE. 2014 ; 9 ( 1 ): e85809 . http://dx.doi.org/10.1371/journal.pone.0085809 17. Nadeem R, Singh M, Nida M, Waheed I, Khan A, Ahmed S et al. Effect of Obstructive Sleep Apnea Hypopnea Syndrome on Lipid Profile: A MetaRegression Analysis. J Clin Sleep Med. 2014 May 15; 10(5): 475–489. http://dx.doi.org/10.5664/jcsm.3690 18. Gunbatar H, Sertogullarindan B, Ekin S, Akdag S, Arisoy A, Sayhan H. The Correlation between Red Blood Cell Distribution Width Levels with the Severity of Obstructive Sleep Apnea and Carotid Intima Media Thickness Med Sci Monit. 2014; 20: 2199–2204. doi: 10.12659/MSM.891001
Toplam 1 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm Makaleler
Yazarlar

Cahit Bilgin

Yayımlanma Tarihi 20 Haziran 2019
Gönderilme Tarihi 5 Aralık 2018
Kabul Tarihi 9 Mart 2019
Yayımlandığı Sayı Yıl 2019 Cilt: 5 Sayı: 2

Kaynak Göster

APA Bilgin, C. (2019). Carotid Intima-Media Thickness in Patients with Obstructive Sleep Apnoea Syndrome. Journal of Human Rhythm, 5(2), 65-73.
AMA Bilgin C. Carotid Intima-Media Thickness in Patients with Obstructive Sleep Apnoea Syndrome. Journal of Human Rhythm. Haziran 2019;5(2):65-73.
Chicago Bilgin, Cahit. “Carotid Intima-Media Thickness in Patients With Obstructive Sleep Apnoea Syndrome”. Journal of Human Rhythm 5, sy. 2 (Haziran 2019): 65-73.
EndNote Bilgin C (01 Haziran 2019) Carotid Intima-Media Thickness in Patients with Obstructive Sleep Apnoea Syndrome. Journal of Human Rhythm 5 2 65–73.
IEEE C. Bilgin, “Carotid Intima-Media Thickness in Patients with Obstructive Sleep Apnoea Syndrome”, Journal of Human Rhythm, c. 5, sy. 2, ss. 65–73, 2019.
ISNAD Bilgin, Cahit. “Carotid Intima-Media Thickness in Patients With Obstructive Sleep Apnoea Syndrome”. Journal of Human Rhythm 5/2 (Haziran 2019), 65-73.
JAMA Bilgin C. Carotid Intima-Media Thickness in Patients with Obstructive Sleep Apnoea Syndrome. Journal of Human Rhythm. 2019;5:65–73.
MLA Bilgin, Cahit. “Carotid Intima-Media Thickness in Patients With Obstructive Sleep Apnoea Syndrome”. Journal of Human Rhythm, c. 5, sy. 2, 2019, ss. 65-73.
Vancouver Bilgin C. Carotid Intima-Media Thickness in Patients with Obstructive Sleep Apnoea Syndrome. Journal of Human Rhythm. 2019;5(2):65-73.