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Acil Servise Başvuran COVID-19 Hastalarında Mukosiliyer Klirensin İncelenmesi

Year 2023, Volume: 14 Issue: 2, 280 - 284, 30.06.2023
https://doi.org/10.18663/tjcl.1246540

Abstract

Öz
Solunum yolu epitelinde yer alan mukosiliyer tabaka, solunum yollarındaki ilk koruma mekanizması olarak görev yapmaktadır. Şiddetli akut solunum sendromu koronavirus-2 de (SARS-Cov-2), diğer bazı solunum yolu virüsleri gibi siliyer hücrelere yapışmakta ve mukosilier aktiviteyi etkilemektedir. Sakkarin testi ile mukosilier klirensin ölçülmesi mümkündür. Çalışmamızda acil servise başvuran hastalarda SARS-CoV 2 ye bağlı olarak gelişen Korona virus hastalığı-2019 (COVİD-19) enfeksiyonunda erken dönemde mukosiliyer klirensin etkisini değerlendirmeyi amaçladık
Gereç ve Yöntem:
Acil servise başvuran ve son 48 saat içerisinde COVID-19 düşündüren yakınmaları olan ve Polimeraz zincir reaksiyonu (PCR) testi çalışılan 84 kişilik hasta grubunda mukosilier klirens zamanı (MCT), sakkarin testi ile ölçülerek sağlıklı gönüllülerde yapılan ölçüm ile karşılaştırılmıştır.
Sonuçlar
PCR pozitif olarak tespit edilen katılmcılarda ortalama MCT 14.58 dakika olarak, sağlıklı gönüllülerde ise ortalama MCT 13.72 dakika olarak ölçüldü. İki grup arasında istatistiksel açıdan fark saptanmadı (p=0,657).
Tartışma
COVID-19 etkeni olan SARS-CoV-2’nin solunum yolu epiteli hasarı yaptığı ve solunum yollarında hastalık oluşturduğu bilinmektedir. Erken dönemde yapılan PCR testlerinde üst solunum yolu mukozasında tespit edilmekle beraber, erken dönemde MCT üzerine etkisi bulunmamaktadır.

References

  • 1. Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, Zhao X, Huang B, Shi W, Lu R, Niu P, Zhan F, Ma X, Wang D, Xu W, Wu G, Gao GF, Tan W. A Novel Coronavirus from Patients with Pneumonia in China, 2019, N Engl J Med 2020; 382: 727-33
  • 2. Advitiya, Kaushik MS, Chakraborty S, Veleri S, Kateriye S, Mucociliary Respiratory Epithelium Integrity in Molecular Defense and Susceptibility to Pulmonary Viral Infections, Biology 2021, 10, 95
  • 3. Afzelius B, Ultrastructure of human nasal epithelium during an episode of coronavirus infection, Virchows Archiv 1994; 424:295-300
  • 4. Li W, Li M, Ou G. COVID-19, cilia and smell, The FEBS Journal (2020), doi:10.1111/febs.15491
  • 5. Munkholm M, Mortensen J. Mucociliary clearance: pathophysiological aspects. Clin Physiol Funct Imaging, 2014, 34, 171-177
  • 6. Pandya VK, Tiwari RS. Nasal mucociliary clearance in health and disease, Indian Journal of Otolaryngology and Head and Neck Surgery, 2006, Vol.58, No.4,
  • 7. Rodrigues F, Freire AP, Uzeloto J, Xavier R, Ito J, Rocha M, Calciolari R, Ramos D, Ramos E. Particularities and Clinical Applicability of Saccharin Transit Time Test. Int Arch Otorhinolaryngol. 2019 Apr;23(2):229-240. doi: 10.1055/s-0038-1676116. Epub 2019 Feb 15.
  • 8. Rodrigues F, Freire AP, Uzeloto J, Xavier R, Ito J, Rocha M, Calciolari R, Ramos D, Ramos E. Particularities and Clinical Applicability of Saccharin Transit Time Test. Int Arch Otorhinolaryngol. 2019 Apr;23(2):229-240.
  • 9. Dülger S, Akdeniz Ö, Solmaz F, Şengören Dikiş Ö, Yildiz T. Evaluation of nasal mucociliary clearance using saccharin test in smokers: A prospective study. Clin Respir J. 2018 Apr;12(4):1706-1710
  • 10. Baby MK, Muthu PK, Johnson P, Kannan S. Effect of cigarette smoking on nasal mucociliary clearance: A comparative analysis using saccharin test. Lung India 2014;31(01):39–42
  • 11. Xavier RF, Ramos D, Ito JT, Rodrigues FM, Bertolini GN, Macchione M, Toledo AC, Ramos EMC. Effects of cigarette smoking intensity on the mucociliary clearance of active smokers. Respiration 2013;86(06):479–485
  • 12. Cinar F, Beder L. Nasal mucociliary clearance in coal mine workers. Otolaryngol Head Neck Surg. 2004 Jun;130(6):767-9.
  • 13. Yoruk O, Ates O, Araz O, Aktan B, Alper F, Sutbeyaz Y, Altas E, Erdogan F,UcuncuH,AkgunM.Theeffectsofsilicaexposureonupperairways and eyes in denim sandblasters. Rhinology. 2008 Dec;46(4):328-33.
  • 14. Deniz M, Gultekin E, Ciftci Z, Alp R, Özdemir DN, Işık A, Demirel OB. Nasalmucociliary clearance in obstructive sleep apnea syndrome patients. Am J Rhinol Allergy 2014;28(05):178–180
  • 15. Kirtsreesakul V, Somjareonwattana P, Ruttanaphol S. The correlation between nasal symptom and mucociliary clearance in allergic rhinitis. Laryngoscope 2009;119(08):1458–1462
  • 16. Valia PP, Valero FC, Pardo JM, Rentero DB, Monte CG. Saccharin test for the study of mucociliary clearance: reference values for a Spanish population. Arch Bronconeumol. 2008 Oct;44(10):540-5.
  • 17. Habesoglu M, Demir K, Yumusakhuylu AC, Sahin Yilmaz A, Oysu C. Does passive smoking have an effect on nasal mucociliary clearance? Otolaryngol Head Neck Surg. 2012 Jul; 147 (1): 152-6.
  • 18. Englender M, Chamovitz D, Harell M. Nasal transit time in normal subjects and pathologic conditions. Otolaryngol Head Neck Surg. 1990 Dec;103(6):909-12
  • 19. Uzeloto JS, Ramos D, Freire AP, Christofaro DG, Ramos EM. Nasal mucociliary transportability of male and female smokers. Braz J Otorhinolaryngol. 2018;84:311-7.
  • 20. Robinot R, Hubert M, Dias de Melo G, Lazarini F, Bruel T, Smith N, Levallois S, Larrous F, Fernandes J, Gellenoncourt S, Rigaud S, Gorgette O, Thouvenot C, Trebeau C, Mallet A, Dumenil G, Gobaa S, Etournay R, Lledo PM, Lecuit M, Bourhy H, Duffy D, Michel V, Schwartz O, Chakrabarti LA. SARS-CoV-2 infection induces the dedifferentiation of multiciliated cells and impairs mucociliary clearance, NATURE COMMUNICATIONS | (2021) 12:4354
  • 21. Özer Öztürk E, Aslan M, Bayındır T. The effect of COVID-19 on nasal mucociliary clearance, Acta Oto-Laryngologica Volume 142, 2022 - Issue 3-4
  • 22. Kahraman ME, Yüksel F, Özbuğday Y, The relationship between Covid-19 and mucociliary clearance, Acta Otolaryngol. 2021 Nov;141(11):989-993.
  • 23. Uğurlu BN, Yerlikaya HS, Aktar Uğurlu G, Aslan Felek S. Evaluation of Nasal Mucociliary Clearance in COVID-19 Patients, KBB ve BBC Dergisi. 2021; 29(2):95-9
  • 24. Koparal M, Kurt E, Altuntaş EE, Doğan F. Assessment of mucociliary clearance as an indicator of nasal function in patients with COVID-19: a cross-sectional study, European Archieves of Oto-Rhino-Laryngology (2921) 278:1863-1868
  • 25. Çeçen A, Bayraktar C, Özgür A, Akgül G, Günal Ö.Evaluation of Nasal Mucociliary Clearance Time in COVID-19 Patients. The Journal of Craniofacial Surgery, 2021; Vol 32, No 8, e702-705

Evaluation of Mucociliary Clearance in COVID-19 Patients Presenting to the Emergency Department

Year 2023, Volume: 14 Issue: 2, 280 - 284, 30.06.2023
https://doi.org/10.18663/tjcl.1246540

Abstract

Abstract
The mucociliary layer in the respiratory epithelium acts as the first protective mechanism in the respiratory tract. Severe acute respiratory syndrome coronavirus-2 (SARS-Cov-2) also adheres to ciliary cells and affects mucociliary activity, like some other respiratory viruses. It is possible to measure mucociliary clearance with the saccharine test. In our study, we aimed to evaluate the effect of mucociliary clearance in the early period of Corona virus disease-2019 (COVID-19) infection due to SARS-CoV 2 in patients admitted to the emergency department.
Methods
Mucociliary clearance time (MCT) was measured with the saccharin test and compared with the measurement made in healthy volunteers in a group of 84 patients who applied to the emergency department and had symptoms suggestive of COVID-19 in the last 48 hours and whose Polymerase chain reaction (PCR) test was studied.
Results
Mean MCT was measured as 14.58 minutes in PCR positive participants and 13.72 minutes in healthy volunteers. There was no statistical difference between the two groups (p=0.657).

Conclusion
It is known that SARS-CoV-2, which is the cause of COVID-19, causes respiratory tract epithelial damage and causes diseases in the respiratory tract. Although it is detected in the upper respiratory tract mucosa in early PCR tests, it is thought to have no effect on MCT in the early period.

References

  • 1. Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, Zhao X, Huang B, Shi W, Lu R, Niu P, Zhan F, Ma X, Wang D, Xu W, Wu G, Gao GF, Tan W. A Novel Coronavirus from Patients with Pneumonia in China, 2019, N Engl J Med 2020; 382: 727-33
  • 2. Advitiya, Kaushik MS, Chakraborty S, Veleri S, Kateriye S, Mucociliary Respiratory Epithelium Integrity in Molecular Defense and Susceptibility to Pulmonary Viral Infections, Biology 2021, 10, 95
  • 3. Afzelius B, Ultrastructure of human nasal epithelium during an episode of coronavirus infection, Virchows Archiv 1994; 424:295-300
  • 4. Li W, Li M, Ou G. COVID-19, cilia and smell, The FEBS Journal (2020), doi:10.1111/febs.15491
  • 5. Munkholm M, Mortensen J. Mucociliary clearance: pathophysiological aspects. Clin Physiol Funct Imaging, 2014, 34, 171-177
  • 6. Pandya VK, Tiwari RS. Nasal mucociliary clearance in health and disease, Indian Journal of Otolaryngology and Head and Neck Surgery, 2006, Vol.58, No.4,
  • 7. Rodrigues F, Freire AP, Uzeloto J, Xavier R, Ito J, Rocha M, Calciolari R, Ramos D, Ramos E. Particularities and Clinical Applicability of Saccharin Transit Time Test. Int Arch Otorhinolaryngol. 2019 Apr;23(2):229-240. doi: 10.1055/s-0038-1676116. Epub 2019 Feb 15.
  • 8. Rodrigues F, Freire AP, Uzeloto J, Xavier R, Ito J, Rocha M, Calciolari R, Ramos D, Ramos E. Particularities and Clinical Applicability of Saccharin Transit Time Test. Int Arch Otorhinolaryngol. 2019 Apr;23(2):229-240.
  • 9. Dülger S, Akdeniz Ö, Solmaz F, Şengören Dikiş Ö, Yildiz T. Evaluation of nasal mucociliary clearance using saccharin test in smokers: A prospective study. Clin Respir J. 2018 Apr;12(4):1706-1710
  • 10. Baby MK, Muthu PK, Johnson P, Kannan S. Effect of cigarette smoking on nasal mucociliary clearance: A comparative analysis using saccharin test. Lung India 2014;31(01):39–42
  • 11. Xavier RF, Ramos D, Ito JT, Rodrigues FM, Bertolini GN, Macchione M, Toledo AC, Ramos EMC. Effects of cigarette smoking intensity on the mucociliary clearance of active smokers. Respiration 2013;86(06):479–485
  • 12. Cinar F, Beder L. Nasal mucociliary clearance in coal mine workers. Otolaryngol Head Neck Surg. 2004 Jun;130(6):767-9.
  • 13. Yoruk O, Ates O, Araz O, Aktan B, Alper F, Sutbeyaz Y, Altas E, Erdogan F,UcuncuH,AkgunM.Theeffectsofsilicaexposureonupperairways and eyes in denim sandblasters. Rhinology. 2008 Dec;46(4):328-33.
  • 14. Deniz M, Gultekin E, Ciftci Z, Alp R, Özdemir DN, Işık A, Demirel OB. Nasalmucociliary clearance in obstructive sleep apnea syndrome patients. Am J Rhinol Allergy 2014;28(05):178–180
  • 15. Kirtsreesakul V, Somjareonwattana P, Ruttanaphol S. The correlation between nasal symptom and mucociliary clearance in allergic rhinitis. Laryngoscope 2009;119(08):1458–1462
  • 16. Valia PP, Valero FC, Pardo JM, Rentero DB, Monte CG. Saccharin test for the study of mucociliary clearance: reference values for a Spanish population. Arch Bronconeumol. 2008 Oct;44(10):540-5.
  • 17. Habesoglu M, Demir K, Yumusakhuylu AC, Sahin Yilmaz A, Oysu C. Does passive smoking have an effect on nasal mucociliary clearance? Otolaryngol Head Neck Surg. 2012 Jul; 147 (1): 152-6.
  • 18. Englender M, Chamovitz D, Harell M. Nasal transit time in normal subjects and pathologic conditions. Otolaryngol Head Neck Surg. 1990 Dec;103(6):909-12
  • 19. Uzeloto JS, Ramos D, Freire AP, Christofaro DG, Ramos EM. Nasal mucociliary transportability of male and female smokers. Braz J Otorhinolaryngol. 2018;84:311-7.
  • 20. Robinot R, Hubert M, Dias de Melo G, Lazarini F, Bruel T, Smith N, Levallois S, Larrous F, Fernandes J, Gellenoncourt S, Rigaud S, Gorgette O, Thouvenot C, Trebeau C, Mallet A, Dumenil G, Gobaa S, Etournay R, Lledo PM, Lecuit M, Bourhy H, Duffy D, Michel V, Schwartz O, Chakrabarti LA. SARS-CoV-2 infection induces the dedifferentiation of multiciliated cells and impairs mucociliary clearance, NATURE COMMUNICATIONS | (2021) 12:4354
  • 21. Özer Öztürk E, Aslan M, Bayındır T. The effect of COVID-19 on nasal mucociliary clearance, Acta Oto-Laryngologica Volume 142, 2022 - Issue 3-4
  • 22. Kahraman ME, Yüksel F, Özbuğday Y, The relationship between Covid-19 and mucociliary clearance, Acta Otolaryngol. 2021 Nov;141(11):989-993.
  • 23. Uğurlu BN, Yerlikaya HS, Aktar Uğurlu G, Aslan Felek S. Evaluation of Nasal Mucociliary Clearance in COVID-19 Patients, KBB ve BBC Dergisi. 2021; 29(2):95-9
  • 24. Koparal M, Kurt E, Altuntaş EE, Doğan F. Assessment of mucociliary clearance as an indicator of nasal function in patients with COVID-19: a cross-sectional study, European Archieves of Oto-Rhino-Laryngology (2921) 278:1863-1868
  • 25. Çeçen A, Bayraktar C, Özgür A, Akgül G, Günal Ö.Evaluation of Nasal Mucociliary Clearance Time in COVID-19 Patients. The Journal of Craniofacial Surgery, 2021; Vol 32, No 8, e702-705
There are 25 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Research Article
Authors

Sinan Cem Uzunget

Zamir Kemal Ertürk 0000-0001-6837-2028

Sevinç Bayrak

Hidayet Can Ünal

Mustafa Hamidullah Türkkanı

Publication Date June 30, 2023
Published in Issue Year 2023 Volume: 14 Issue: 2

Cite

APA Uzunget, S. C., Ertürk, Z. K., Bayrak, S., Ünal, H. C., et al. (2023). Acil Servise Başvuran COVID-19 Hastalarında Mukosiliyer Klirensin İncelenmesi. Turkish Journal of Clinics and Laboratory, 14(2), 280-284. https://doi.org/10.18663/tjcl.1246540
AMA Uzunget SC, Ertürk ZK, Bayrak S, Ünal HC, Türkkanı MH. Acil Servise Başvuran COVID-19 Hastalarında Mukosiliyer Klirensin İncelenmesi. TJCL. June 2023;14(2):280-284. doi:10.18663/tjcl.1246540
Chicago Uzunget, Sinan Cem, Zamir Kemal Ertürk, Sevinç Bayrak, Hidayet Can Ünal, and Mustafa Hamidullah Türkkanı. “Acil Servise Başvuran COVID-19 Hastalarında Mukosiliyer Klirensin İncelenmesi”. Turkish Journal of Clinics and Laboratory 14, no. 2 (June 2023): 280-84. https://doi.org/10.18663/tjcl.1246540.
EndNote Uzunget SC, Ertürk ZK, Bayrak S, Ünal HC, Türkkanı MH (June 1, 2023) Acil Servise Başvuran COVID-19 Hastalarında Mukosiliyer Klirensin İncelenmesi. Turkish Journal of Clinics and Laboratory 14 2 280–284.
IEEE S. C. Uzunget, Z. K. Ertürk, S. Bayrak, H. C. Ünal, and M. H. Türkkanı, “Acil Servise Başvuran COVID-19 Hastalarında Mukosiliyer Klirensin İncelenmesi”, TJCL, vol. 14, no. 2, pp. 280–284, 2023, doi: 10.18663/tjcl.1246540.
ISNAD Uzunget, Sinan Cem et al. “Acil Servise Başvuran COVID-19 Hastalarında Mukosiliyer Klirensin İncelenmesi”. Turkish Journal of Clinics and Laboratory 14/2 (June 2023), 280-284. https://doi.org/10.18663/tjcl.1246540.
JAMA Uzunget SC, Ertürk ZK, Bayrak S, Ünal HC, Türkkanı MH. Acil Servise Başvuran COVID-19 Hastalarında Mukosiliyer Klirensin İncelenmesi. TJCL. 2023;14:280–284.
MLA Uzunget, Sinan Cem et al. “Acil Servise Başvuran COVID-19 Hastalarında Mukosiliyer Klirensin İncelenmesi”. Turkish Journal of Clinics and Laboratory, vol. 14, no. 2, 2023, pp. 280-4, doi:10.18663/tjcl.1246540.
Vancouver Uzunget SC, Ertürk ZK, Bayrak S, Ünal HC, Türkkanı MH. Acil Servise Başvuran COVID-19 Hastalarında Mukosiliyer Klirensin İncelenmesi. TJCL. 2023;14(2):280-4.


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