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BENİGN PROSTAT HİPERPLAZİSİ DÜŞÜK VE YÜKSEK DERECELİ PIN VE PROSTAT ADENOKARSİNOMUNDA CD24 EKSPRESYONU

Year 2010, Volume: 17 Issue: 2, 14 - 18, 30.06.2010

Abstract

Amaç: CD24 aktive endotel hücreleri ve trombositler üzerinde eksprese edilen bir adezyon reseptörü olan P-selektin'in alternatif ligandı olarak fonksiyon gören son zamanlarda tanımlanan yeni bir prognostik belirleyici gendir. CD24'ün çeşitli solid tümörlerin metastatik tümör gelişiminde rol oynadığı düşünülmektedir. Çalışmamızda prostat adenokarsinomlarında, düşük ve yüksek dereceli prostat intraepitelyal neoplazilerde (PIN) ve benign prostat hiperplazisinde (BPH) CD24 ekspresyonunun histopatolojik parametreler ve serum PSA seviyesi ile ilişkisini değerlendirmeyi amaçladık.
Gereç ve Yöntem: Yetmişaltı prostat adenokarsinomu, 16 düşük dereceli PIN, 16 yüksek dereceli PIN ve 14 BPH vakasında immunohistokimyasal olarak CD24 ekspresyonunu inceleyerek bulgularımızın histopatolojik parametreler ve serum PSA seviyesi ile ilişkisini değerlendirdik.
Bulgular: Prostat adenokarsinomu ve PIN materyallerinde CD24 ekspesyonu saptanırken benign prostat dokularında ekspresyon izlenmedi. 76 prostat adenokarsinomu olgusunun 48'inde (%63.2) CD24 immunoreaktivitesi saptandı. Prostat adenokarsinomunda sitoplazmik CD24 ekspresyonu Gleason skoru (p=0.000, r= 0.465) ve PSA seviyesi (p=0.022, r=0.263) ile anlamlı şekilde pozitif korele bulundu.
Sonuçlar: Bulgularımız prostat adenokarsinomlarında pozitif CD24 ekspresyonunun yüksek Gleason skoru ve yüksek PSA seviyesi ile birlikteliğini gösterdi. CD24'ün prostat kanseri için önemli bir moleküler belirleyici olabileceği kanısındayız.

References

  • Jemal A, Siegel R, Ward E, Murray T, Xu J, Thun MJ. Cancer statistics 2007. CA Cancer J Clin 2007;57:43- 66.
  • May F, Hartung R, Breul J. The ability of the American Joint Committee on Cancer Staging system to predict progression-free survival after radical prostatectomy. BJU Int 2001; 88(7):702-7
  • Fischer GF, Majdic O, Gadd S, Knapp W. Signal transduction in lymphocytic and myeloid cells via CD24 a new member of phosphoinositol-anchored membrane molecules. J Immunol 1990;144:638-641
  • Pirruccello SJ, LeBien TW. The human B-cell associated antigen CD24 is a single chain sialoglycoprotein. J Immunol 1986:136: 3779-3784
  • Kristiansen G, Sammar M, Altevogt P. Tumour biological aspects of CD24, a mucin-like adhesion molecule. J Mol Histol 2004;35: 255-262
  • Nestl A, Von Stein OD, Zatloukal K, Thies WG, Herrlich P, Hofmann M et al. Gene expression patterns associated with the metastatic phenotype in rodent and human tumors. Cancer Res 2001;61:1569-1577
  • Jackson D, Waibel R, Weber E, Bell J, Stahel RA. CD24, a signal-transducing molecule expressed on human B cells, is a major surface antigen on small cell lung carcinomas. Cancer Res 1992;52: 5264-5270
  • Fogel M, Friederichs J, Zeller Y, Husar M, Smirnov A, Roitman L et al. CD24 is a marker for human breast c a r c i n o m a . C a n c e r L e t t 1 9 9 9 ; 1 4 3 : 8 7 - 9 4
  • Kristiansen G, Pilarsky C, Pervan J, Stürzebecher B, Stephan C, Jung K et al. CD24 expression is a significant predictor of PSA relapse and poor prognosis in low grade or organ confined prostate cancer. Prostate 2004;58:183-192
  • Kristiansen G, Denkert C, Schlüns K, Dahl E, Pilarsky C, Hauptmann S. CD24 is expressed in ovarian cancer and is a new independent prognostic marker of patient survival. Am J Pathol 2002;161:1215-1221
  • Aigner S, Ruppert M, Hubbe M, Sammar M, Sthoeger Z, Butcher EC et al. Heat stable antigen (mouse CD24) supports myeloid cell binding to endothelial and platelet P-selectin. Int Immunol 1995;7:1557-1565
  • Aigner S, Sthoeger ZM, Fogel M, Weber E, Zarn J, Ruppert M et al. CD24, a mucin-type glycoprotein, is a ligand for P-selectin on human tumor cells. Blood 1997;89:3385-3395
  • Epstein JI, Algaba F, Alsbrook WC. Tumours of the prostate. In: Eble JN, Sauter G, Epstein JI, Sesterhenn IA. Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs. Lyon, IARC Press,2004: 160
  • Baumann P, Cremers N, Kroese F, Orend G, Chiquet- Ehrismann R, Uede T et al. CD24 expression causes the acquisition of multiple cellular properties associated with tumor growth and metastasis. 2005;65(23):10783- 93
  • The metastasis-associated gene CD24 is regulated by Ral GTPase and is a mediator of cell proliferation and survival in human cancer. Cancer Res. 2006;66(4):1917- 22
  • Analysis of gene expression identifies candidate markers and pharmacological targets in prostate cancer.Cancer Res. 2001;61(16):5974-8
  • Singh D, Febbo PG, Ross K, Jackson DG, Manola J, Ladd C et al. Gene expression correlates of clinical prostate cancer behavior. 2002;1(2):203-9
  • Lim SC. CD24 and human carcinoma: tumor biological aspects. 2005;59( 2):351-4
  • Weichert W, Denkert C, Burkhardt M, Gansukh T, Bellach J, Altevogt P et al. Cytoplasmic CD24 expression in colorectal cancer independently correlates with shortened patient survival. Clin Cancer Res 2005;11(18):6574-6581

CD24 expression in benign prostate hyperplasia low and high grade PIN and prostate adenocarcinoma

Year 2010, Volume: 17 Issue: 2, 14 - 18, 30.06.2010

Abstract

Amaç: CD24 aktive endotel hücreleri ve trombositler üzerinde eksprese edilen bir adezyon reseptörü olan P-selektinin alternatif ligandý olarak fonksiyon gören son zamanlarda tanýmlanan yeni bir prognostik belirleyici gendir. CD24ün çeþitli solid tümörlerin metastatik tümör geliþiminde rol oynadýðý düþünülmektedir. Çalýþmamýzda prostat adenokarsinomlarýnda, düþük ve yüksek dereceli prostat intraepitelyal neoplazilerde (PIN) ve benign prostat hiperplazisinde (BPH) CD24 ekspresyonunun histopatolojik parametreler ve serum PSA seviyesi ile iliþkisini deðerlendirmeyi amaçladýk. Gereç ve Yöntem: Yetmiþaltý prostat adenokarsinomu, 16 düþük dereceli PIN, 16 yüksek dereceli PIN ve 14 BPH vakasýnda immunohistokimyasal olarak CD24 ekspresyonunu inceleyerek bulgularýmýzýn histopatolojik parametreler ve serum PSA seviyesi ile iliþkisini deðerlendirdik. Bulgular: Prostat adenokarsinomu ve PIN materyallerinde CD24 ekspesyonu saptanýrken benign prostat dokularýnda ekspresyon izlenmedi. 76 prostat adenokarsinomu olgusunun 48inde (%63.2) CD24 immunoreaktivitesi saptandý. CD24 ekspresyonu prostat adenokarsinomu ve yüksek dereceli PIN gruplarýnda BPH grubu ie karþýlaþtýrýldýðýnda anlamlý þekilde yüksek bulundu (p=0,000, p=0,040 ). Prostat adenokarsinomunda sitoplazmik CD24 ekspresyonu Gleason skoru (p=0.000, r= 0.465) ve PSA seviyesi (p=0.022, r=0.263) ile anlamlý þekilde pozitif korele bulundu. Sonuçlar: Bulgularýmýz prostat adenokarsinomlarýnda pozitif CD24 ekspresyonunun yüksek Gleason skoru ve yüksek PSA seviyesi ile birlikteliðini gösterdi. CD24ün prostat kanseri için önemli bir moleküler belirleyici olabileceði kanýsýndayýz.

References

  • Jemal A, Siegel R, Ward E, Murray T, Xu J, Thun MJ. Cancer statistics 2007. CA Cancer J Clin 2007;57:43- 66.
  • May F, Hartung R, Breul J. The ability of the American Joint Committee on Cancer Staging system to predict progression-free survival after radical prostatectomy. BJU Int 2001; 88(7):702-7
  • Fischer GF, Majdic O, Gadd S, Knapp W. Signal transduction in lymphocytic and myeloid cells via CD24 a new member of phosphoinositol-anchored membrane molecules. J Immunol 1990;144:638-641
  • Pirruccello SJ, LeBien TW. The human B-cell associated antigen CD24 is a single chain sialoglycoprotein. J Immunol 1986:136: 3779-3784
  • Kristiansen G, Sammar M, Altevogt P. Tumour biological aspects of CD24, a mucin-like adhesion molecule. J Mol Histol 2004;35: 255-262
  • Nestl A, Von Stein OD, Zatloukal K, Thies WG, Herrlich P, Hofmann M et al. Gene expression patterns associated with the metastatic phenotype in rodent and human tumors. Cancer Res 2001;61:1569-1577
  • Jackson D, Waibel R, Weber E, Bell J, Stahel RA. CD24, a signal-transducing molecule expressed on human B cells, is a major surface antigen on small cell lung carcinomas. Cancer Res 1992;52: 5264-5270
  • Fogel M, Friederichs J, Zeller Y, Husar M, Smirnov A, Roitman L et al. CD24 is a marker for human breast c a r c i n o m a . C a n c e r L e t t 1 9 9 9 ; 1 4 3 : 8 7 - 9 4
  • Kristiansen G, Pilarsky C, Pervan J, Stürzebecher B, Stephan C, Jung K et al. CD24 expression is a significant predictor of PSA relapse and poor prognosis in low grade or organ confined prostate cancer. Prostate 2004;58:183-192
  • Kristiansen G, Denkert C, Schlüns K, Dahl E, Pilarsky C, Hauptmann S. CD24 is expressed in ovarian cancer and is a new independent prognostic marker of patient survival. Am J Pathol 2002;161:1215-1221
  • Aigner S, Ruppert M, Hubbe M, Sammar M, Sthoeger Z, Butcher EC et al. Heat stable antigen (mouse CD24) supports myeloid cell binding to endothelial and platelet P-selectin. Int Immunol 1995;7:1557-1565
  • Aigner S, Sthoeger ZM, Fogel M, Weber E, Zarn J, Ruppert M et al. CD24, a mucin-type glycoprotein, is a ligand for P-selectin on human tumor cells. Blood 1997;89:3385-3395
  • Epstein JI, Algaba F, Alsbrook WC. Tumours of the prostate. In: Eble JN, Sauter G, Epstein JI, Sesterhenn IA. Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs. Lyon, IARC Press,2004: 160
  • Baumann P, Cremers N, Kroese F, Orend G, Chiquet- Ehrismann R, Uede T et al. CD24 expression causes the acquisition of multiple cellular properties associated with tumor growth and metastasis. 2005;65(23):10783- 93
  • The metastasis-associated gene CD24 is regulated by Ral GTPase and is a mediator of cell proliferation and survival in human cancer. Cancer Res. 2006;66(4):1917- 22
  • Analysis of gene expression identifies candidate markers and pharmacological targets in prostate cancer.Cancer Res. 2001;61(16):5974-8
  • Singh D, Febbo PG, Ross K, Jackson DG, Manola J, Ladd C et al. Gene expression correlates of clinical prostate cancer behavior. 2002;1(2):203-9
  • Lim SC. CD24 and human carcinoma: tumor biological aspects. 2005;59( 2):351-4
  • Weichert W, Denkert C, Burkhardt M, Gansukh T, Bellach J, Altevogt P et al. Cytoplasmic CD24 expression in colorectal cancer independently correlates with shortened patient survival. Clin Cancer Res 2005;11(18):6574-6581
There are 19 citations in total.

Details

Primary Language English
Subjects Dentistry
Journal Section Research Articles
Authors

Nermin Karahan

Şirin Başpınar

Alim Koşar

Korkut Bozkurt This is me

Halil İ Saraçoğlu This is me

Nilgün Kapucuoğlu

Publication Date June 30, 2010
Submission Date December 5, 2009
Published in Issue Year 2010 Volume: 17 Issue: 2

Cite

Vancouver Karahan N, Başpınar Ş, Koşar A, Bozkurt K, Saraçoğlu Hİ, Kapucuoğlu N. CD24 expression in benign prostate hyperplasia low and high grade PIN and prostate adenocarcinoma. Med J SDU. 2010;17(2):14-8.

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