Relationship Between Apnea Hypopnea Index, Neutrophil Lymphocyte Ratio And Platelet Lymphocyte Ratio in Patients With Obstructive Sleep Apnea Syndrome
Abstract
Abstract
Aim: The aim of this study was to assess the association
between apnea-hypopnea index (AHI) with neutrophil
lymphocyte ratio (NLO) and platelet lymphocyte ratio
(PLO) according to gender in patients with obstructive
sleep apnea syndrome (OSAS) and to investigate whether
PLO and NLO can be a predictor of disease severity
before polysomnography.
Material and Method This study was designed as
retrospective and cross-sectional, between March 2018
and April 2018, The patients who underwent PSG who
were admitted to the Otorhinolaryngology outpatient clinic
of Adana City Training and Research Hospital with the
complaint of snoring and sleep apnea were evaluated. The
study population was divided in to four groups: (i) first
group described as; AHI 0-4.9 (ii) second group described
as; 5-14.9 (iii) third group described as; AHI 15-29.9 and
(iv) fourth group decribed as AHI ≥30 according to
polyspmnography (PSG). Neutrophil, lymphocyte and
platelet results were evaluated routinely from the blood
count results.
Results: Of the patients included in the study, 106 were
male and 32 were female. The mean age was 45.3 (43,3
for males and 50,4 for females), the mean body mass
index (BMI) was 30.1 (min: 19 - max: 51), the mean AHI
was 23.7 (min: 0,3 max: 103), the mean PLO was 113,1
(male:111.2 , female: 119.5) and the mean NLO was 1,93
(male:1.99, female:1.72 ) . In our study, the highest PLO
value was found in group 2 and the highest NLO value was
found in group 3. The lowest NLO and PLO values were
found in group 4, unlike the results from other studies.
However, no statistically significant difference was found
between the groups.
Conclusıons: In OSAS, there is a need for more
comprehensive prospective and multi-centered study to
better understand AHI and NLO, PLO relationship,
Key words: Obstructive sleep apnea syndrome (OSAS),
Polysomnography (PSG), neutrophil, lymphocyte
References
- KAYNAKLAR
- 1. Leon E. et. al.; Red Cell Distribution Width in Obstructive Sleep Apnea Arch Bronconeumol. 2017;53(3):114–1192. Feliciano, A., et al., Hematological evaluation in males with obstructive sleep apnea before and after positive airway pressure. Revista Portuguesa de Pneumologia (English Edition), 2017. 23(2): p. 71-78.3. Chang-Xing Shen et. al.,Evaluation of the predictive value of red blood cell distribution width for onset of cerebral infarction in the patients with obstructive sleep apnea hypopnea syndrome) Medicine (Baltimore). 2017 Jul;96(29):e73204. Erdim İ. Et. al.; Blood count values and ratios for predicting sleep apnea in obese children Int J Pediatr Otorhinolaryngol. 2017 Aug;995. Sökücü S. et. al., . Can Red blood Cell Distribution Width Predict Severity of Obstructive Sleep Apnea Syndrome? J Clin Sleep Med. 2012 Oct 15;8(5):521-56. Subias L. Et. al.;, Red Cell Distribution Width in Obstructive Sleep Apnea Arch Bronconeumol. 2017;53(3):114–1197. A. Felicianoa et. al., Hematological evaluation in males with obstructive sleep apnea before and after positive airway pressure Rev Port Pneumol. 2017;23(2):71---78
- 8. Ozsu S et. al.; ,Red cell distribution width in patients with obstructive sleep apnea syndrome. Lung. 2012 Jun;190(3):319-26. 9. Kıvanç T. Et. al., | Importance of laboratory parameters in patients withobstructive sleep apnea and their relationship withcardiovascular diseases 2017 Wiley Periodicals J Clin Lab Anal. 2018 Jan;32(1).
- 10. Kurt O. et. al., The The importance of laboratory parameters in patients with obstructive sleep apneasyndrome. 2013 Blood Coagul Fibrinolysis. 2013 Jun;24(4):371-4
Obstrüktif Uyku Apne Sendromlu Hastalarda Apne Hipopne İndeksi ile Nötrofil Lenfosit Oranı ve Platelet Lenfosit Oranının İlişkisi
Abstract
Amaç: Bu çalışmanın
amacı, OUAS’lı hastalarda, apne-hipopne indeksi (AHİ) ile nötrofil lenfosit oranı (NLO) ve platelet
lenfosit oranı (PLO) arasındaki ilişkinin değerlendirilmesi ve NLO ile PLO nın
polisomnografi öncesi hastalığın şiddeti ile ilgili bir belirteç olup
olamayacağının incelenmesidir.
Materyal ve Metot: : Calışmamız, retrospektif ve
kesitsel bir calışma olup, çalışmamızda mart
2018- nisan 2018 tarihleri arasında Adana Şehir Eğitim ve Araştırma Hastanesi
“Kulak Burun Boğaz polikliniğine horlama ve uyku apnesi şikayeti ile başvurup
polisomnografi (PSG) yapılan hasta kayıtları değerlendirildi. PSG yapılan
hastalardan Apne Hipopne indeksi
(AHİ) 0-4.9 olan 1. Grup, AHİ 5-14.9
olan 2. Grup, 15-29.9 olan 3. grup
ve AHİ
>30 olan hasta 4.
Grup olarak alındı. Calışmaya dahil
edilen hastalardan rutin olarak istenen kan sayımı sonuclarından nötrofil,
lenfosit ve platelet sonuçlarına bakıldı.
Nötrofil, lenfosit ve plateletleri etkileyecek sistemik hastalığı olanlar çalışma
dışı bırakıldı.
Bulgular: Çalışmaya 138
hasta alındı. Çalışmaya dahil edilen hastaların 106 erkek, 26’sı kadındı. Genel
yaş ortalaması 45,3 (erkeklerde 43,3; kadınlarda 50,4), vücut kitle endeksi
(BMI) ortalaması 30.1 (min: 19 – max: 51) bulundu. AHİ ortalaması 23,7 (min: 0,
3-max:103), PLO ortalaması 113,1 (erkeklerde 111.2, kadınlarda 119.5) ve NLO
ortalaması 1,93 ( erkeklerde 1.99, kadınlarda 1.72) olarak saptandı. Alt grupların demografik
verileri, BMI, AHİ, PLO ve NLO değerleri
Tablo-1-2 ve 3 te verildi.
Bizim çalışmamızda en yüksek PLO değeri grup 2 de , en yüksek NLO değeri grup 3 te
saptandı. En düşük NLO ve PLO değeri diğer çalışmalardaki sonuçlardan farklı
olarak grup 4 te saptandı. Fakat gruplar
arası incelemede istatistiksel olarak anlamlı bir farklılık saptanmadı.
Hastalığın şiddeti ile PLO ve NLO arasında bir ilişki görülmedi. Bu durumun
sebebi, hasta popülasyonunun görece az olması ya da gruplar arası dağılım
eşitsizliği olabilir
Sonuç: OUAS’de AHİ ile NLO ve PLO ilişkisini daha net anlayabilmek
için daha kapsamlı prospektif ve cok merkezli calışmalara ihtiyac vardır
References
- KAYNAKLAR
- 1. Leon E. et. al.; Red Cell Distribution Width in Obstructive Sleep Apnea Arch Bronconeumol. 2017;53(3):114–1192. Feliciano, A., et al., Hematological evaluation in males with obstructive sleep apnea before and after positive airway pressure. Revista Portuguesa de Pneumologia (English Edition), 2017. 23(2): p. 71-78.3. Chang-Xing Shen et. al.,Evaluation of the predictive value of red blood cell distribution width for onset of cerebral infarction in the patients with obstructive sleep apnea hypopnea syndrome) Medicine (Baltimore). 2017 Jul;96(29):e73204. Erdim İ. Et. al.; Blood count values and ratios for predicting sleep apnea in obese children Int J Pediatr Otorhinolaryngol. 2017 Aug;995. Sökücü S. et. al., . Can Red blood Cell Distribution Width Predict Severity of Obstructive Sleep Apnea Syndrome? J Clin Sleep Med. 2012 Oct 15;8(5):521-56. Subias L. Et. al.;, Red Cell Distribution Width in Obstructive Sleep Apnea Arch Bronconeumol. 2017;53(3):114–1197. A. Felicianoa et. al., Hematological evaluation in males with obstructive sleep apnea before and after positive airway pressure Rev Port Pneumol. 2017;23(2):71---78
- 8. Ozsu S et. al.; ,Red cell distribution width in patients with obstructive sleep apnea syndrome. Lung. 2012 Jun;190(3):319-26. 9. Kıvanç T. Et. al., | Importance of laboratory parameters in patients withobstructive sleep apnea and their relationship withcardiovascular diseases 2017 Wiley Periodicals J Clin Lab Anal. 2018 Jan;32(1).
- 10. Kurt O. et. al., The The importance of laboratory parameters in patients with obstructive sleep apneasyndrome. 2013 Blood Coagul Fibrinolysis. 2013 Jun;24(4):371-4
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Clinical Sciences |
| Journal Section | Orginal Article |
| Authors | |
| Publication Date | December 13, 2018 |
| Published in Issue | Year 2018 Volume: 6 Issue: 3 |