Research Article
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Drosophila melanogaster’in farklı soylarında astaksantin’in in vivo kronik etkilerinin belirlenmesi

Year 2021, Volume: 11 Issue: 1, 135 - 146, 15.01.2021
https://doi.org/10.17714/gumusfenbil.754474

Abstract

Rodofit olarak bilinen alglerde bulunan ve kırmızı renkli bir pigment olan astaksantin (ASTA) terpeni bir tetraterpendir. Çalışmada ASTA’nın doz-süre etkileşimine bağlı olarak olası toksik ve genotoksik etkileri araştırılmıştır. ASTA’nın toksik etkisi, Drosophila melanogaster’in Oregon-R yabanıl soyunda in vivo ömür uzunluğu testi ile belirlenmiştir. Bu amaçla ergin dişi ve erkek bireyler farklı dozlarda ASTA içeren (25, 50, 100 ve 200 ppm) besiyerinde kronik olarak beslenmiştir. Kontrol grubunda ortalama ömür uzunluğu dişilerde 49.07±1.92 gün iken erkeklerde 51.01±2.12 gündür. Bu değerler en düşük ve en yüksek ASTA uygulama gruplarında (25-200 ppm) dişilerde sırasıyla 32.06±1.50 ve 27.06±1.18 gün, erkeklerde de 32.45±1.48 ve 23.52±0.92 gün olarak bulunmuştur. ASTA’nın kontrol ve uygulama gruplarına ait sonuçlar birbiriyle karşılaştırıldığı zaman hem dişi hem de erkek popülasyonunda ortalama ömür uzunluğunun doz-süre etkileşimine bağlı olarak kısaldığı gözlenmiştir (p<0.05). ASTA terpeninin genotoksik etkisi de yine D.melanogaster’de somatik mutasyon ve rekombinasyon testi (SMART) ile belirlenmiştir. SMART sonucunda elde edilen verilere göre tüm ASTA uygulama gruplarında (50, 100, 200 ve 400 ppm) konsantrasyon artışına bağlı olarak klon indüksiyon frekansında artış gözlenmiştir. Bu sonuçlar ASTA’nın somatik mutasyonları uyardığını göstermektedir.

Supporting Institution

Atatürk Üniversitesi Bilimsel Araştırma Projeleri Yönetim Birimi

Project Number

FHD–2019-7000

Thanks

Atatürk Üniversitesi Bilimsel Araştırma Projeleri Yönetim Birimi Başkanlığı'na destekleri için teşekkür ederiz.

References

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Determination of ın vivo chronic effects of astaxanthin in different strains of drosophila melanogaster

Year 2021, Volume: 11 Issue: 1, 135 - 146, 15.01.2021
https://doi.org/10.17714/gumusfenbil.754474

Abstract

Astaxanthine (ASTA) terpene, a red pigment found in algae known as rhodopite, is a tetraterpene. In this study, possible toxic and genotoxic effects of the ASTA were investigated depending on the dose-time interaction. The toxic effect of the ASTA was determined by in vivo longevity test in Oregon-R wild strain of Drosophila melanogaster. For this purpose, adult female and male individuals were chronically fed on media containing different doses of the ASTA (25, 50, 100 and 200 ppm). While the average life span in the control group is 49.07±1.92 days in females, it is 51.01±2.12 days in males. These values are 32.06±1.50 and 27.06±1.18 days in females in the lowest and highest ASTA application groups (25-200 ppm), 32.45±1.48 and 23.52±0.92 in males, respectively. When the results of the control and application groups of the ASTA terpene were compared, it was observed that the average life span decreased in both female and male populations depending on the dose-time interaction (p<0.05). The genotoxic effect of the ASTA terpene was also determined by the somatic mutation and recombination test (SMART) in D.melanogaster. According to the data obtained from the SMART result, an increase in clone induction frequency was observed in all the ASTA application groups (50, 100, 200 and 400 ppm) due to concentration increase. These results show that ASTA stimulates somatic mutations.

Project Number

FHD–2019-7000

References

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  • Edwards, J.A., Bellion, P., Beilstein, P., Rümbeli, R. ve Schierle, J. (2016). Review of genotoxicity and rat carcinogenicity investigations with astaxanthin. Regulatory Toxicology and Pharmacology, 75, 5-19.
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  • Gören, A.C. (2002). Bazı Sideritis (Sideritis argyrea, Sideritis dichotoma, Sideritis trojana) türlerinin diterpenik bileşenlerinin izolasyonu ve yapılarının tayini. Doktora Tezi, Balıkesir Üniversitesi, Fen Bilimleri Enstitüsü, Kimya Anabilim Dalı, Balıkesir.
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  • Guzman-Rincon, J. and Graf, U. (1995). Drosophila melanogaster somatic mutation and recombination test as a biomonitor. Environmental Science Research, 50, 169-182.
  • Güneş, E. and Danacıoğlu, D.A. (2018). The effect of olive (Olea europaea L.) phenolics and sugar on Drosophila melanogaster’s development. Animal Biology,68(4), 367-385.
  • Hammer, K. A., Carson, C.F. ve Riley, T.V. (1999). Antimicrobial activity of essential oils and other plant extracts. Journal of Applied Microbiology, 86, 985-990.
  • Huangfu, J., Liu, J., Sun, Z., Wang, M., Jiang, Y., Chen, Z. Y. ve Chen, F. (2013). Antiaging effects of astaxanthin-rich alga Haematococcus pluvialis on fruit flies under oxidative stress. Journal of Agricultural and Food Chemistry, 61(32), 7800-7804.
  • Hussein, G., Goto, H., Oda, S., Sankawa, U., Matsumoto, K. ve Watanabe, H. (2006). Antihypertensive potential and mechanism of action of astaxanthin: III. antioxidant and histopathological effects in spontaneously hypertensive rats. Biological and Pharmaceutical Bulletin, 29(4), 684-688.
  • İpek, E., Zeytinoglu, H., Okay, S., Tuylu, B.A., Kurkcuoglu, M. ve Baser, K.H.C. (2005). Genotoxicity and antigenotoxicity of Origanum oil and carvacrol evaluatedby ames Salmonella/Microsomal test. Food and Chemistry, 93, 551-556.
  • Kamaya, Y., Tokita, N. ve Suzuki, K. (2005). Effects of dehydroabietic acid and abietic acid on survival, reproduction, and growth of the crustacean Daphnia magna. Ecotoxicology and Environmental Safety, 61(1), 83-88.
  • Kasımoğlu, C. ve Uysal, H. (2016). Farklı test sistemleri ile somatik hücrelerde profenofos genotoksisitesine karşı kuşburnu (Rosa canina L.) ekstrelerinin doğal bir antigenotoksik ajan olarak kullanılması. Cumhuriyet Üniversitesi Fen Fakültesi Fen Bilimleri Dergisi, 37, 1.
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  • Kırca, A., Özkan, M. ve Cemeroğlu, B. (2006). Stability of black carrot anthocyanins in various fruit juices and nectars. Food Chemistry, 97, 598-605.
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There are 63 citations in total.

Details

Primary Language Turkish
Subjects Engineering
Journal Section Articles
Authors

Handan Uysal 0000-0002-4290-8223

Hatice Çelik 0000-0003-2531-6020

Project Number FHD–2019-7000
Publication Date January 15, 2021
Submission Date June 18, 2020
Acceptance Date December 6, 2020
Published in Issue Year 2021 Volume: 11 Issue: 1

Cite

APA Uysal, H., & Çelik, H. (2021). Drosophila melanogaster’in farklı soylarında astaksantin’in in vivo kronik etkilerinin belirlenmesi. Gümüşhane Üniversitesi Fen Bilimleri Dergisi, 11(1), 135-146. https://doi.org/10.17714/gumusfenbil.754474