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Year 2014, Volume: 2 Issue: 1, 94 - 101, 26.02.2014

Abstract

The interactions between foods and drugs are clinically important subjects. When some foods are taken with some drugs simultaneously, it is observed that there are some changes in the bioavailability, pharmacokinetic, pharmacodynamic, and therapeutic effects of the drugs. In addition, the therapeutic effects of many drugs change depending on individuals’ nutrition status. Some drugs affect the bioavailability and metabolism of the nutrients or taste sensation and appetite status. As a result of this, there may be certain clinical problems which have important outcomes such as the deficiencies of some vitamins and minerals, the changes of fluid-electrolyte balance and body weight. Although many of the mechanisms about food and drug interactions have been clarified, future research is expected to deal with the unclarified points.

References

  • Akazawa H, Kohno H, Tokuda H, et al. Antiinflammatory and anti-tumor-promoting effects of 5deprenyllupulonol C and other compounds from hop (Humulus lupulus L.). Chemistry & Biodiversity 2012;9:1045-1054.
  • Andersen V, Petersen N, Larsen NE, et al. Intestinal first pass metabolism of midazolam in liver cirrhosis – effect of grapefruit juice. Br J Clin Pharmacol 2002; 54:120-124.
  • Bailey DG. Fruit juice inhibition of uptake transport: A new type of food-drug interaction. Br J Clin Pharmacol 2010; 70:645-655.
  • Bailey DG, Dresser GK, Bend JR. Bergamottin, lime juice, and red wine as inhibitors of cytochrome P450 3A4 activity: comparison with grapefruit juice. Clin Pharmacol Ther 2003;73:529-537.
  • Bailey DG, Spence JD, Edgar B, et al. Ethanol enhances the hemodynamic effects of felodipine. Clin Invest Med 1989;12(6):357-362.
  • Benton RE, Honig PK, Zamani K, et al. Grapefruit juice alters terfenadine pharmacokinetics, resulting in prolongation of repolarization on the electrocardiogram. Clin Pharmacol Ther 1996;59(4):383-388.
  • Brill S, Zimmermann C, Berger K, et al. In vitro interactions with repeated grapefruit juice administration-to peel or not to peel? Planta Med 2009;75:332-335.
  • Chan LN. Drug-nutrient interaction in clinical nutrition. Curr Opin Clin Nutr Metab Care 2002;5:327-332.
  • Dahan A, Altman H. Food–drug interaction: Grapefruit juice augments drug bioavailability mechanism, extent and relevance. European Journal of Clinical Nutrition 2004;58:1-9.
  • Castro WV, Mertens-Talcott S, Rubner A, et al. Variation of flavonoids and furanocoumarins in grapefruit juices: a potential source of variability in grapefruit juice-drug interaction studies. J Agric Food Chem 2006;54:249-255.
  • Demet MM, Deniz F, Şimşek E, et al. Psikotrop ilaç yazılma sıklığı ve ilaç etkileşimleri: Sitokrom P450 sistemi. Klinik Psikofarmakoloji Bülteni 2003; 13:43
  • Edwards DJ, Fitzsimmons ME, Schuetz EG, et al. 6′,7′-Dihydroxybergamottin in grapefruit juice and Seville orange juice: effects on cyclosporine disposition, enterocyte CYP3A4, and P-glycoprotein. Clin Pharmacol Ther 1999;65:237-244.
  • Genser D. Food and drug interaction: consequences for the nutrition/health status. Ann Nutr Metab 2008;52 (Suppl1):29-32.
  • Guo LQ, Fukuda K, Ohta T, et al. Role of furanocoumarin derivatives on grapefruit juice-mediated inhibition of human CYP3A activity. Drug Metab Dispos 2000;28:766-771.
  • Hidaka M, Okumura M, Fujita K, et al. Effects of pomegranate juice on human cytochrome p450 3A (CYP3A) and carbamazepine pharmacokinetics in rats. Drug Metab Dispos 2005;33:644-648.
  • Honda Y, Ushigome F, Koyabu N, et al. Effects of grapefruit juice and orange juice components on Pglycoprotein- and MRP2-mediated drug efflux. British Journal of Pharmacology 2004;143:856-864.
  • Jang GR, Harris RZ. Drug interactions involving ethanol and alcoholic beverages. Expert Opin Drug Metab Toxicol 2007;3:719-731.
  • Krenz M, Korthuis RJ. Moderate ethanol ingestion and cardiovascular protection: from epidemiologic associations to cellular mechanisms. J Mol Cell Cardiol 2012;52:93-104.
  • McCabe BJ, Frankel EH, Wolfe JJ. 2003. Handbook of Food-Drug Interactions Washington DC: CRC Press.
  • Misaka S, Nakamura R, Uchida S, et al. Effect of 2 weeks' consumption of pomegranate juice on the pharmacokinetics of a single dose of midazolam: an open-label, randomized, single-center, 2-period crossover study in healthy Japanese volunteers. . Clin Ther 2011;33:246-252.
  • Mouly SJ, Matheny C, Paine MF, et al. Variation in oral clearance of saquinavir is predicted by CYP3A5*1 genotype but not by enterocyte content of cytochrome P450 3A5. Clin Pharmacol Ther 2005;78:605-618.
  • Nieminen TH, Hagelberg NM, Saari TI, et al. Grapefruit juice enhances the exposure to oral oxycodone. Basic&Clinical,Pharmacology&Toxicology 2010;107:782-788.
  • Oliveira-Freitas VL, Dalla Costa T, Manfro RC, et al. Influence of purple grape juice in cyclosporine bioavailability. J Ren Nutr 2010;20(5):309-313.
  • Paine MF, Oberlies NH.Clinical relevance of the small intestine as an organ of drug elimination: drug-fruit juice interactions. . Expert Opin Drug Metab Toxicol Sci 2007;3:67-80.
  • Peltoniemi MA, Saari TI, Hagelberg NM. S-ketamine concentrations are greatly increased by grapefruit juice. Eur J Clin Pharmacol 2012;68:979-986.
  • Pillai U, Muzaffar J, Sen S, et al. Grapefruit juice and verapamil: a toxic cocktail. South Med J 2009; 102(3):308-309.
  • Piver B, Berthou F, Dreano Y, et al. Inhibition of CYP3A, CYP1A and CYP2E1 activities by resveratrol and other non volatile red wine components. Toxicology Letters 2001;125 83-91.
  • Qiao J, Gu C, Shang W, et al. Effect of green tea on pharmacokinetics of 5-fluorouracil in rats and pharmacodynamics in human cell lines in vitro. Food and Chemical Toxicology 2011;49:1410-1415.
  • Roncoroni C, Rizzi N, Brunialti E, et al. Molecular imaging of cytochrome P450 activity in mice. Pharmacol Res 2012;65(5):531-536.
  • Schmiedlin-Ren P, Edwards DJ, Fitzsimmons ME, et al. Mechanisms of enhanced oral availability of CYP3A4 substrates by grapefruit constituents. Decreased enterocyte CYP3A4 concentration andmechanism-based inactivation by furanocoumarins. Drug Metab Dispos 1997;25:1228-1233.
  • Seidegård J, Randvall G, Nyberg L, et al. Grapefruit juice interaction with oral budesonide: Equal effect on immediate-release and delayed-release formulations. Pharmazie 2009;64(7):461-465.
  • Stupans L, Tan HW, Kirlich A, et al. Inhibition of CYP3A-mediated oxidation in human hepatic microsomes by the dietary derived complex phenol, gallic acid. J Pharm Pharmacol 2002;54:269-275.
  • Sunaga K, Ohkawa K, Nakamura K, et al Mechanismbased inhibition of recombinant human cytochrome P450 3A4 by tomato juice extract. Biol Pharm Bull 2012;35:329-334.
  • Tapaninen T, Neuvonen PJ, Niemi M. Orange and apple juice greatly reduce the plasma concentrations of the OATP2B1 substrate aliskiren. Br J Clin Pharmacol 2011;71:718-726.
  • Uesawa Y, Abe M, Fukuda E, et al. Construction of a model to estimate the CYP3A inhibitory effect of grapefruit juice. Pharmazie 2011;66:525-528.
  • Van Vlierberghe H, Van Durme F, Verdievel H, et al. Influence of low-dose oral contraceptives, alcohol, and grapefruit on. Dig Dis Sci 2001;46(1):133-139.
  • Vischini G, Niscola P, Stefoni A, et al. Increased plasma levels of tacrolimus after ingestion of green tea. Am J Kidney Dis 2011;58:329.
  • Weathermon R, Crabb DW. Alcohol and medication interactions. Alcohol Research & Health 2011;40-54.
  • Weber A, Jäger R, Börner A, et al. Can grapefruit juice influence ethinylestradiol bioavailability? Contraception 1996;53(1):41-47.
  • Won CS, Oberlies NH, Paine MF. Mechanisms underlying food–drug interactions: Inhibition of intestinal metabolism andtransport.Pharmacology&Therapeutics 2012;136:186-201.

BESİN-İLAÇ ETKİLEŞİMLERİNE GÜNCEL BAKIŞ: İÇECEKLER

Year 2014, Volume: 2 Issue: 1, 94 - 101, 26.02.2014

Abstract

ÖZET

Besin-ilaç etkileşimleri klinik öneme sahip bir konudur. Bazı içecekler, çeşitli ilaçlarla eşzamanlı alındığında ilaçların; biyoyararlılığı, farmakokinetik, farmakodinamik ve töropatik etkilerinde değişim gözlenmektedir. Bunun yanı sıra, birçok ilacın töropatik etkisi bireyin beslenme durumuna bağlı olarak değişmektedir. Bazı ilaçlar, bazı besin öğelerinin biyoyararlılığını ve metabolizmasını veya bireyin tat algısı ve iştah durumunu etkilemektedir. Bunun sonucunda, bazı vitamin ve minerallerin eksikliği, sıvı-elektrolit dengesi ve beden ağırlığı değişimleri gibi önemli sonuçları olan klinik sorunlar görülebilir. Besin-ilaç etkileşimleri konusunda çoğu mekanizma aydınlatılmış olsa da, gelecekte yapılacak araştırmalardan aydınlatılmamış noktaları ele alması beklenmektedir.

THE CURRENT VIEW OF FOOD AND DRUG INTERACTIONS: BEVERAGES

ABSTRACT

The interactions between foods and drugs are clinically important subjects. When some foods are taken with some drugs simultaneously, it is observed that there are some changes in the bioavailability, pharmacokinetic, pharmacodynamic, and therapeutic effects of the drugs. In addition, the therapeutic effects of many drugs change depending on individuals' nutrition status. Some drugs affect the bioavailability and metabolism of the nutrients or taste sensation and appetite status. As a result of this, there may be certain clinical problems which have important outcomes such as the deficiencies of some vitamins and minerals, the changes of fluid-electrolyte balance and body weight. Although many of the mechanisms about food and drug interactions have been clarified, future research is expected to deal with the unclarified points.

Keywords: Drug, Food, Interaction, Nutrient, Metabolism.

 

References

  • Akazawa H, Kohno H, Tokuda H, et al. Antiinflammatory and anti-tumor-promoting effects of 5deprenyllupulonol C and other compounds from hop (Humulus lupulus L.). Chemistry & Biodiversity 2012;9:1045-1054.
  • Andersen V, Petersen N, Larsen NE, et al. Intestinal first pass metabolism of midazolam in liver cirrhosis – effect of grapefruit juice. Br J Clin Pharmacol 2002; 54:120-124.
  • Bailey DG. Fruit juice inhibition of uptake transport: A new type of food-drug interaction. Br J Clin Pharmacol 2010; 70:645-655.
  • Bailey DG, Dresser GK, Bend JR. Bergamottin, lime juice, and red wine as inhibitors of cytochrome P450 3A4 activity: comparison with grapefruit juice. Clin Pharmacol Ther 2003;73:529-537.
  • Bailey DG, Spence JD, Edgar B, et al. Ethanol enhances the hemodynamic effects of felodipine. Clin Invest Med 1989;12(6):357-362.
  • Benton RE, Honig PK, Zamani K, et al. Grapefruit juice alters terfenadine pharmacokinetics, resulting in prolongation of repolarization on the electrocardiogram. Clin Pharmacol Ther 1996;59(4):383-388.
  • Brill S, Zimmermann C, Berger K, et al. In vitro interactions with repeated grapefruit juice administration-to peel or not to peel? Planta Med 2009;75:332-335.
  • Chan LN. Drug-nutrient interaction in clinical nutrition. Curr Opin Clin Nutr Metab Care 2002;5:327-332.
  • Dahan A, Altman H. Food–drug interaction: Grapefruit juice augments drug bioavailability mechanism, extent and relevance. European Journal of Clinical Nutrition 2004;58:1-9.
  • Castro WV, Mertens-Talcott S, Rubner A, et al. Variation of flavonoids and furanocoumarins in grapefruit juices: a potential source of variability in grapefruit juice-drug interaction studies. J Agric Food Chem 2006;54:249-255.
  • Demet MM, Deniz F, Şimşek E, et al. Psikotrop ilaç yazılma sıklığı ve ilaç etkileşimleri: Sitokrom P450 sistemi. Klinik Psikofarmakoloji Bülteni 2003; 13:43
  • Edwards DJ, Fitzsimmons ME, Schuetz EG, et al. 6′,7′-Dihydroxybergamottin in grapefruit juice and Seville orange juice: effects on cyclosporine disposition, enterocyte CYP3A4, and P-glycoprotein. Clin Pharmacol Ther 1999;65:237-244.
  • Genser D. Food and drug interaction: consequences for the nutrition/health status. Ann Nutr Metab 2008;52 (Suppl1):29-32.
  • Guo LQ, Fukuda K, Ohta T, et al. Role of furanocoumarin derivatives on grapefruit juice-mediated inhibition of human CYP3A activity. Drug Metab Dispos 2000;28:766-771.
  • Hidaka M, Okumura M, Fujita K, et al. Effects of pomegranate juice on human cytochrome p450 3A (CYP3A) and carbamazepine pharmacokinetics in rats. Drug Metab Dispos 2005;33:644-648.
  • Honda Y, Ushigome F, Koyabu N, et al. Effects of grapefruit juice and orange juice components on Pglycoprotein- and MRP2-mediated drug efflux. British Journal of Pharmacology 2004;143:856-864.
  • Jang GR, Harris RZ. Drug interactions involving ethanol and alcoholic beverages. Expert Opin Drug Metab Toxicol 2007;3:719-731.
  • Krenz M, Korthuis RJ. Moderate ethanol ingestion and cardiovascular protection: from epidemiologic associations to cellular mechanisms. J Mol Cell Cardiol 2012;52:93-104.
  • McCabe BJ, Frankel EH, Wolfe JJ. 2003. Handbook of Food-Drug Interactions Washington DC: CRC Press.
  • Misaka S, Nakamura R, Uchida S, et al. Effect of 2 weeks' consumption of pomegranate juice on the pharmacokinetics of a single dose of midazolam: an open-label, randomized, single-center, 2-period crossover study in healthy Japanese volunteers. . Clin Ther 2011;33:246-252.
  • Mouly SJ, Matheny C, Paine MF, et al. Variation in oral clearance of saquinavir is predicted by CYP3A5*1 genotype but not by enterocyte content of cytochrome P450 3A5. Clin Pharmacol Ther 2005;78:605-618.
  • Nieminen TH, Hagelberg NM, Saari TI, et al. Grapefruit juice enhances the exposure to oral oxycodone. Basic&Clinical,Pharmacology&Toxicology 2010;107:782-788.
  • Oliveira-Freitas VL, Dalla Costa T, Manfro RC, et al. Influence of purple grape juice in cyclosporine bioavailability. J Ren Nutr 2010;20(5):309-313.
  • Paine MF, Oberlies NH.Clinical relevance of the small intestine as an organ of drug elimination: drug-fruit juice interactions. . Expert Opin Drug Metab Toxicol Sci 2007;3:67-80.
  • Peltoniemi MA, Saari TI, Hagelberg NM. S-ketamine concentrations are greatly increased by grapefruit juice. Eur J Clin Pharmacol 2012;68:979-986.
  • Pillai U, Muzaffar J, Sen S, et al. Grapefruit juice and verapamil: a toxic cocktail. South Med J 2009; 102(3):308-309.
  • Piver B, Berthou F, Dreano Y, et al. Inhibition of CYP3A, CYP1A and CYP2E1 activities by resveratrol and other non volatile red wine components. Toxicology Letters 2001;125 83-91.
  • Qiao J, Gu C, Shang W, et al. Effect of green tea on pharmacokinetics of 5-fluorouracil in rats and pharmacodynamics in human cell lines in vitro. Food and Chemical Toxicology 2011;49:1410-1415.
  • Roncoroni C, Rizzi N, Brunialti E, et al. Molecular imaging of cytochrome P450 activity in mice. Pharmacol Res 2012;65(5):531-536.
  • Schmiedlin-Ren P, Edwards DJ, Fitzsimmons ME, et al. Mechanisms of enhanced oral availability of CYP3A4 substrates by grapefruit constituents. Decreased enterocyte CYP3A4 concentration andmechanism-based inactivation by furanocoumarins. Drug Metab Dispos 1997;25:1228-1233.
  • Seidegård J, Randvall G, Nyberg L, et al. Grapefruit juice interaction with oral budesonide: Equal effect on immediate-release and delayed-release formulations. Pharmazie 2009;64(7):461-465.
  • Stupans L, Tan HW, Kirlich A, et al. Inhibition of CYP3A-mediated oxidation in human hepatic microsomes by the dietary derived complex phenol, gallic acid. J Pharm Pharmacol 2002;54:269-275.
  • Sunaga K, Ohkawa K, Nakamura K, et al Mechanismbased inhibition of recombinant human cytochrome P450 3A4 by tomato juice extract. Biol Pharm Bull 2012;35:329-334.
  • Tapaninen T, Neuvonen PJ, Niemi M. Orange and apple juice greatly reduce the plasma concentrations of the OATP2B1 substrate aliskiren. Br J Clin Pharmacol 2011;71:718-726.
  • Uesawa Y, Abe M, Fukuda E, et al. Construction of a model to estimate the CYP3A inhibitory effect of grapefruit juice. Pharmazie 2011;66:525-528.
  • Van Vlierberghe H, Van Durme F, Verdievel H, et al. Influence of low-dose oral contraceptives, alcohol, and grapefruit on. Dig Dis Sci 2001;46(1):133-139.
  • Vischini G, Niscola P, Stefoni A, et al. Increased plasma levels of tacrolimus after ingestion of green tea. Am J Kidney Dis 2011;58:329.
  • Weathermon R, Crabb DW. Alcohol and medication interactions. Alcohol Research & Health 2011;40-54.
  • Weber A, Jäger R, Börner A, et al. Can grapefruit juice influence ethinylestradiol bioavailability? Contraception 1996;53(1):41-47.
  • Won CS, Oberlies NH, Paine MF. Mechanisms underlying food–drug interactions: Inhibition of intestinal metabolism andtransport.Pharmacology&Therapeutics 2012;136:186-201.
There are 40 citations in total.

Details

Primary Language Turkish
Journal Section Derleme Bölümü
Authors

Neslihan Çelik

Nevin Şanlıer

Publication Date February 26, 2014
Submission Date February 26, 2014
Published in Issue Year 2014 Volume: 2 Issue: 1

Cite

APA Çelik, N., & Şanlıer, N. (2014). BESİN-İLAÇ ETKİLEŞİMLERİNE GÜNCEL BAKIŞ: İÇECEKLER. ERÜ Sağlık Bilimleri Fakültesi Dergisi, 2(1), 94-101.