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Şanlıurfa’da Metanol Zehirlenmesine Bağlı Ölümler

Year 2024, Volume: 8 Issue: 1, 4 - 10, 29.04.2024
https://doi.org/10.46332/aemj.1277010

Abstract

Amaç: Metanol, odunun destrüktif distilasyonundan elde edilen berrak, renksiz ve yüksek derecede toksik bir maddedir. COVİD-19 pandemi döneminde özellik kronik alkol kullanıcılarının ucuz alkollü içecek ve kolonya gibi alternatif içecekler tükettiği ve toksikolojik analizlerde alkollü sıvılarda etanolün yerine daha ucuz olan metanol kullanılmasına bağlı metanol intoksikasyonlarında artış olmuştur. Bu çalışmada, Şanlıurfa Adli Tıp Şube Müdürlüğü’nde otopsisi yapılan ve ölüm nedeni metanol zehirlenmesi olarak belirlenen olguların değerlendirilmesi amaçlanmıştır.

Araçlar ve Yöntem: 1 Ocak 2016- 1 Kasım 2022 yıllar arasındaki Şanlıurfa Adli Tıp Şube Müdürlüğü’nde ölüm nedeni metil alkol intoksikasyonu olarak belirlenen 15 olgu incelenmiştir. Olguların sosyodemografik verileri, olay yeri bilgileri, klinik bulgular ve hastane yatış verileri ile, olayların yıllara göre dağılımı, alınan içecek türü ve toksikolojik & patolojik veriler değerlendirilmiştir.

Bulgular: Olguların tümü erkekti. Yaş ortalaması 52.1 olarak hesaplandı. Tüketilen içeceklerin 8'inde kolonya, 4'ünde sahte rakı, viski ve votka olduğu belirlenirken, 3'ünde içeceğin türü belirlenemedi.

Sonuç: Alkollü sıvı tüketiminin arttığı dönemlerde sıvılara etanol yerine metanol karıştırılabileceği unutulmamalı ve intoksikasyonlara karşı halkı bilinçlendirici çalışmalar yapılmalıdır. Metanol intoksikasyonuna karşı alkollü içecek ve kolonya gibi alkollü antiseptiklerin üretim ve satışı aşamasında kontroller arttırılarak gerekli yaptırımlar uygulanmalıdır.

References

  • 1. Koca T, Hilal A. Metil Alkol (Metanol) İntoksikasyonu. Adli Tıp Bülteni. 2020;25(2):128-138.
  • 2. Mutlu E, Balcı Y, Seçkin Ç Muğla’da Metanol Zehirlenmesine Bağlı Ölümler: Olgu Serisi. Adli Tıp Bülteni. 2022;27(2):150-156.
  • 3. Taşkın Ö, Akpınar AA, Dişel NR. Metil Alkol Zehirlenmeleri. Anatolian J Emerg Med. 2022;5(1):37-42.
  • 4. Pohanish RP. Sittig’s Handbook of Toxic and Hazardous Chemicals and Carcinogens. USA: Elsevier; 2012.
  • 5. Vural S. Transdermal Methanol Intoxication Via Folk Medicine. J Emerg Med Case Rep. 2019;10(2):50-52.
  • 6. Patil AM, Meshram SK, Kharat RD et al. Profile of Fatal Methyl Alcohol Poisoning Outbreak-A Medicolegal Autopsy Case Study. Indian J Med Forensic Med Toxicol. 2013;7(1):16-20.
  • 7. Gautam M, Dandu H, Siddiqui SS, Atam V, Kumari S, Rathore S. Acute Methanol Toxicity: Clinical Correlation with Autopsy Findings, a Descriptive Study. J Assoc Physicians India. 2022;70(6):11-12.
  • 8. Kim H-J, Na J-Y, Lee Y-J, Park J-T, Kim H-S. An autopsy case of methanol induced intracranial hemorrhage. Int J Clin Exp Pathol. 2015;8(10):13643.
  • 9. Wang LL, Zhang M, Zhang W et al. A retrospective study of poisoning deaths from forensic autopsy cases in northeast China (Liaoning). J Forensic Leg Med. 2019;63:7-10.
  • 10. Lachenmeier DW, Samokhvalov AV, Leitz J et al. The composition of unrecorded alcohol from eastern Ukraine: is there a toxicological concern beyond ethanol alone? Food Chem Toxicol. 2010;48(10): 2842-2847.
  • 11. Global Information System on Alcohol and Health (GISAH). Available from: http://apps.who.int/gho/data/node.main.GISAH?lang¼en Erişim tarihi 13 December, 2022.
  • 12. Arslan MM, Zeren C, Aydin Z, et al. Analysis of methanol and its derivatives in illegally produced alcoholic beverages. J Forensic Leg Med. 2015;33:56-60.
  • 13. Zeren C, Aydin Z, Yonden Z, Bucak S. Composition of bogma raki, Turkish traditional alcoholic beverage. J Food Technol. 2012;10(3):87-89.
  • 14. Kurtaş Ö, Imre KY, Özer E, et al. The evaluation of deaths due to methyl alcohol intoxication. Biomed. Res. 2017;28(8):3680-3687.
  • 15. Azmak D. Methanol related deaths in Edirne. Leg Med. 2006;8(1):39-42.
  • 16. Hovda KE, Lao YE, Gadeholt G, et al. Formate test for bedside diagnosis of methanol poisoning. Basic Clin. Pharmacol. Toxicol. 2021;129(1):86-88.
  • 17. DJ D. DiMaio VJM: Forensic Pathology. CRC Press. BOCa Raton, l993:507-547.
  • 18. Mittal B, Desai A, Khade K. Methyl alcohol poisoning: an autopsy study of 28 cases. J Postgrad Med. 1991;37(1):9-13.
  • 19. Graw M, Haffner H-T, Althaus L, Besserer K, Voges S. Invasion and distribution of methanol. Arch Toxicol. 2000;74(6):313-321.
  • 20. Zakharov S, Kurcova I, Navratil T, Salek T, Komarc M, Pelclova D. Is the measurement of serum formate concentration useful in the diagnostics of acute methanol poisoning? A prospective study of 38 patients. Basic Clin Pharmacol Toxicol. 2015;116(5): 445-451.

Deaths associated with Methanol Poisoning in Şanlıurfa

Year 2024, Volume: 8 Issue: 1, 4 - 10, 29.04.2024
https://doi.org/10.46332/aemj.1277010

Abstract

Purpose: Methanol, is a clear, colourless, highly toxic substance obtained from the destructive distillation of wood. During the COVID-19 pandemic, chronic alcohol users consumed alternatives such as cologne and cheap alcohol, the toxicology analyses showed that there was an increase in methanol poisoning due to the use of cheaper methanol instead of ethanol in alcoholic liquids. The aim of this study was to evaluate autopsy cases in the Şanlıurfa Forensic Medicine Branch Directorate that were recorded as cause of death from methanol poisoning.

Materials and Methods: 15 cases whose cause of death was determined to be methyl alcohol intoxication were examined at Şanlıurfa Forensic Medicine Branch Directorate between 1 January 2016 and 1 November 2022. Sociodemographic data of the cases, crime scene information, clinical findings and hospitalization data, distribution of events according to years, type of beverage consumed toxicological and pathological data were evaluated.

Results: All of the cases were male. The mean age was calculated as 52.1. The drinks consumed were determined to be cologne in 8 cases, fake raki, whisky and vodka in 4, and the type of drink could not be determined in 3 cases.

Conclusion: It should not be forgotten that in times of increased alcohol consumption, methanol can be mixed with liquids in place of ethanol, and programs should be implemented to inform the public about intoxications. The necessary precautions against methanol intoxication should be taken by increasing control at the production and sales stages of alcoholic drinks and antiseptics containing alcohol, such as cologne.

References

  • 1. Koca T, Hilal A. Metil Alkol (Metanol) İntoksikasyonu. Adli Tıp Bülteni. 2020;25(2):128-138.
  • 2. Mutlu E, Balcı Y, Seçkin Ç Muğla’da Metanol Zehirlenmesine Bağlı Ölümler: Olgu Serisi. Adli Tıp Bülteni. 2022;27(2):150-156.
  • 3. Taşkın Ö, Akpınar AA, Dişel NR. Metil Alkol Zehirlenmeleri. Anatolian J Emerg Med. 2022;5(1):37-42.
  • 4. Pohanish RP. Sittig’s Handbook of Toxic and Hazardous Chemicals and Carcinogens. USA: Elsevier; 2012.
  • 5. Vural S. Transdermal Methanol Intoxication Via Folk Medicine. J Emerg Med Case Rep. 2019;10(2):50-52.
  • 6. Patil AM, Meshram SK, Kharat RD et al. Profile of Fatal Methyl Alcohol Poisoning Outbreak-A Medicolegal Autopsy Case Study. Indian J Med Forensic Med Toxicol. 2013;7(1):16-20.
  • 7. Gautam M, Dandu H, Siddiqui SS, Atam V, Kumari S, Rathore S. Acute Methanol Toxicity: Clinical Correlation with Autopsy Findings, a Descriptive Study. J Assoc Physicians India. 2022;70(6):11-12.
  • 8. Kim H-J, Na J-Y, Lee Y-J, Park J-T, Kim H-S. An autopsy case of methanol induced intracranial hemorrhage. Int J Clin Exp Pathol. 2015;8(10):13643.
  • 9. Wang LL, Zhang M, Zhang W et al. A retrospective study of poisoning deaths from forensic autopsy cases in northeast China (Liaoning). J Forensic Leg Med. 2019;63:7-10.
  • 10. Lachenmeier DW, Samokhvalov AV, Leitz J et al. The composition of unrecorded alcohol from eastern Ukraine: is there a toxicological concern beyond ethanol alone? Food Chem Toxicol. 2010;48(10): 2842-2847.
  • 11. Global Information System on Alcohol and Health (GISAH). Available from: http://apps.who.int/gho/data/node.main.GISAH?lang¼en Erişim tarihi 13 December, 2022.
  • 12. Arslan MM, Zeren C, Aydin Z, et al. Analysis of methanol and its derivatives in illegally produced alcoholic beverages. J Forensic Leg Med. 2015;33:56-60.
  • 13. Zeren C, Aydin Z, Yonden Z, Bucak S. Composition of bogma raki, Turkish traditional alcoholic beverage. J Food Technol. 2012;10(3):87-89.
  • 14. Kurtaş Ö, Imre KY, Özer E, et al. The evaluation of deaths due to methyl alcohol intoxication. Biomed. Res. 2017;28(8):3680-3687.
  • 15. Azmak D. Methanol related deaths in Edirne. Leg Med. 2006;8(1):39-42.
  • 16. Hovda KE, Lao YE, Gadeholt G, et al. Formate test for bedside diagnosis of methanol poisoning. Basic Clin. Pharmacol. Toxicol. 2021;129(1):86-88.
  • 17. DJ D. DiMaio VJM: Forensic Pathology. CRC Press. BOCa Raton, l993:507-547.
  • 18. Mittal B, Desai A, Khade K. Methyl alcohol poisoning: an autopsy study of 28 cases. J Postgrad Med. 1991;37(1):9-13.
  • 19. Graw M, Haffner H-T, Althaus L, Besserer K, Voges S. Invasion and distribution of methanol. Arch Toxicol. 2000;74(6):313-321.
  • 20. Zakharov S, Kurcova I, Navratil T, Salek T, Komarc M, Pelclova D. Is the measurement of serum formate concentration useful in the diagnostics of acute methanol poisoning? A prospective study of 38 patients. Basic Clin Pharmacol Toxicol. 2015;116(5): 445-451.
There are 20 citations in total.

Details

Primary Language English
Subjects Clinical Sciences
Journal Section Original Articles
Authors

İsmail Altın 0000-0001-7185-2620

Ahmet Sedat Dündar 0000-0002-4029-2613

Early Pub Date April 5, 2024
Publication Date April 29, 2024
Published in Issue Year 2024 Volume: 8 Issue: 1

Cite

APA Altın, İ., & Dündar, A. S. (2024). Deaths associated with Methanol Poisoning in Şanlıurfa. Ahi Evran Medical Journal, 8(1), 4-10. https://doi.org/10.46332/aemj.1277010
AMA Altın İ, Dündar AS. Deaths associated with Methanol Poisoning in Şanlıurfa. Ahi Evran Med J. April 2024;8(1):4-10. doi:10.46332/aemj.1277010
Chicago Altın, İsmail, and Ahmet Sedat Dündar. “Deaths Associated With Methanol Poisoning in Şanlıurfa”. Ahi Evran Medical Journal 8, no. 1 (April 2024): 4-10. https://doi.org/10.46332/aemj.1277010.
EndNote Altın İ, Dündar AS (April 1, 2024) Deaths associated with Methanol Poisoning in Şanlıurfa. Ahi Evran Medical Journal 8 1 4–10.
IEEE İ. Altın and A. S. Dündar, “Deaths associated with Methanol Poisoning in Şanlıurfa”, Ahi Evran Med J, vol. 8, no. 1, pp. 4–10, 2024, doi: 10.46332/aemj.1277010.
ISNAD Altın, İsmail - Dündar, Ahmet Sedat. “Deaths Associated With Methanol Poisoning in Şanlıurfa”. Ahi Evran Medical Journal 8/1 (April 2024), 4-10. https://doi.org/10.46332/aemj.1277010.
JAMA Altın İ, Dündar AS. Deaths associated with Methanol Poisoning in Şanlıurfa. Ahi Evran Med J. 2024;8:4–10.
MLA Altın, İsmail and Ahmet Sedat Dündar. “Deaths Associated With Methanol Poisoning in Şanlıurfa”. Ahi Evran Medical Journal, vol. 8, no. 1, 2024, pp. 4-10, doi:10.46332/aemj.1277010.
Vancouver Altın İ, Dündar AS. Deaths associated with Methanol Poisoning in Şanlıurfa. Ahi Evran Med J. 2024;8(1):4-10.

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