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EVALUATION OF PHYTOCHEMICAL CONSTITUENTS IN THE WHOLE PLANT PARTS OF HEXANE EXTRACT OF SOME TRADITIONAL MEDICINAL PLANTS BY GC-MS ANALYSIS

Year 2020, Volume: 6 Issue: 2, 57 - 67, 29.12.2020

Abstract

The aim of this study was to determine the phytochemical components from the hexane extract of some medicinal plants (Salvia palaestina BENTHAM, Alkanna trichophila var. mardinensis HUB.-MOR.(an endemic species), Scutellaria orientalis L.) and to evaluate its biological activity by GC-MS analysis. The chemical components in this hexane extract were subjected to the Agilent 7890B GC-5977MSD model Gas Chromatography - Mass Spectrometric analysis. Thirty two chemical compounds have been identified in the plant extracts. This definition is based on peak area, retention time, molecular weight, and molecular formula. In this research, Bis (2-ethylhexyl) phthalate, tricosane, docosane, transcaryophyllene, nonacosane, beta-Cubebene, Trichlorfon, Naphthalene, 1,2,3,4,4a, 5,6,8a-octahydro-4a, 8-dimethyl -2- (1-methylet henyl) -, [2R, 3-Aminophenol were found predominantly compounds in extracts. These compounds, which we identified in our study, have a wide range of biological activity and have been found to have high therapeutic value. They are candidate plants to be medicines with various active ingredient content.

Supporting Institution

Batman University

References

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Year 2020, Volume: 6 Issue: 2, 57 - 67, 29.12.2020

Abstract

References

  • [1] Güner, A., Özhatay, N., Ekim, T., Başer, KHC. (editors). “Flora of Turkey and the East Aegean Islands (Suppl. 2)”, Vol. 11. Edinburgh, UK: Edinburgh University Press. 2000.
  • [2] Acıbuca, V and Bostan, Budak D., “Dünya’da ve Türkiye’de Tıbbi ve Aromatik Bitkilerin Yeri ve Önemi”, Çukurova Journal of Agricultural and Food Sciences, 33(1): 37-44, 2018.
  • [3] Başer, H.C., “Sustainable Wild Harvesting of Medicinal and Aromatic Plants: An Educational Aprroach, Harvesting On Non-Wood Forest Products”, Seminar Proceedings, Menemen-İzmir, Turkey, 2000.
  • [4] Bayramoğlu, M.M, Toksoy, D., Şen, G., “Türkiye’de Tıbbi Bitki Ticareti”, II. Ormancılıkta Sosyo-Ekonomik Sorunlar Kongresi, 19-21 Şubat, Sdü, Isparta, 2009. [5] Mojab, F., Kamalinejad, M., Ghaderi, N., Vahidipour, H.R,. “Phytochemical screening of some species of Iranian plants”, Iranian Journal of Pharmaceutical Research, 2(2):77-82, 2003. [6] Davis, P.H., Milli, R.R., Kit, Tan. , “Flora of Turkey and The East Aegean Island (Supplement)” Edinburgh Univ. Press., Vol. 10, Edinburgh, 1988.
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  • [8] Wei, G., Hui, C., Lin, K., Xue-ru, L., Chao-ying, M. and He-zhong, J., “ Composition And Bioactivity of the Essential Oil from the Leaves of Lindera setchuenensis”, Chemistry of Natural Compounds, 52 (3): 520-522, 2016.
  • [9] Molnár, P. B., Csengele, B., Erdei, A. L., Takeshi, F., Pál, V., Katalin, J. J. And Kárpáti, Z., “ Identification of the Female-Produced Sex Pheromone of an Invasive Greenhouse Pest, the European Pepper Moth (Duponchelia fovealis)”, Journal of Chemical Ecology, 44:257-267, 2018.
  • [10] Teal, J. P. E.A., . Tumlinson, R. H.. Heath, R., “Chemical and behavioral analyses of volatile sex pheromone components released by calling Heliothis virescens (F.) females (Lepidoptera: Noctuidae)”, Journal of Chemical Ecology January , 12 (1), 107-126, 1986.
  • [11] Ulitzur, S. and Hastings, J. W., “Evidence for tetradecanal as the natural aldehyde in bacterial bioluminescence”. Proceedings of the National Academy of Sciences of the United States of America, 76(1): 265-267, 1979.
  • [12] Chung, I.M., Ahmad, A., Kim, S.J., Naik, P.M., Nagella, P., “Composition of the essential oil constituents from leaves and stems of Korean Coriandrum sativum and their immunotoxicity activity on the Aedes aegypti L.”, Immunopharmacology and Immunotoxicology, 34(1):152-6,2012.
  • [13] Černohlávková, J., Jarkovský, J., Jiří, H., Effects of fungicides mancozeb and dinocap on carbon and nitrogen mineralization in soils. Ecotoxicology and Environmental Safety, 72 (1), 80-85. 2009.
  • [14] Habib, M. R., Karim, M. R. “Antimicrobial and Cytotoxic Activity of Di-(2-ethylhexyl) Phthalate and Anhydrosophoradiol-3-acetate Isolated from Calotropis gigantea (Linn.) Flower”, Journal Mycobiology, 37 (1): 31-36,2009.
  • [15] Lee, K. H., Kim, J. H., Lim, D. S., Kim, C. H., “Anti‐leukaemic and Anti‐mutagenic Effects of Di(2‐ethylhexyl)phthalate Isolated from Aloe vera Linne”, Journal of Pharmacy and Pharmacology, https://doi.org/10.1211/0022357001774246, 2010.
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  • [17] Pinto, S. A. H., Pinto, L. M. S., Guedes, M. A., Cunha, G. M. A., Chaves, M. H., Santos, F. A., Rao, V. S., “Antinoceptive effect of triterpenoid alpha,beta-amyrin in rats on orofacial pain induced by formalin and capsaicin”, Phytomedicine, 15(8):630-634, 2008.
  • [18] Ma, J., Lu, N., Qin, W., Xu, R., Wang, Y., Chen, X., “Differential responses of eight cyanobacterial and green algal species, to carbamate insecticides”, Ecotoxicology and Environmental Safety, 63 (2):268-274, 2006.
  • [19] Bakthavatsalam, N., Tandon, P.L., Bhagat, D., “Trichogrammatids: Behavioural Ecology”. In: Sithanantham S., Ballal C., Jalali S., Bakthavatsalam N. (eds) Biological Control of Insect Pests Using Egg Parasitoids. Springer, New Delhi. https://doi.org/10.1007/978-81-322-1181-5_5., 2013.
  • [20] Tao, C., Wu, J., Liu, Y., Liu, M., Yang, R. and Zhaolin Lv., “Antimicrobial activities of bamboo (Phyllostachys heterocycla cv. pubescens) leaf essential oil and its major components”, European Food Research and Technology, 244:881–891, 2018.
  • [21] Khatua, S., Pandey, A. and Biswas, S. J., “Phytochemical evaluation and antimicrobial properties of Trichosanthes dioica root extract”, Journal of Pharmacognosy and Phytochemistry, 5(5): 410-413, 2016.
  • [22] Bakr, R. O., El-Naa, M. M., Zaghloul, S. S. and Omar, M. M. BMC Complementary Medicine and Therapies,17: 1-13, 2017.
  • [23] Paul, A.V.N., Singh, S. and Singh, A.K. “Kairomonal effect of some saturated hydrocarbons on the egg parasitoids, Trichogramma brasiliensis (Ashmead) and Trichogramma exiguum (Hymenoptera: Trichogrammatidae)”, Journal of Applied Entomology, 126: 409-416.2002.
  • [24] Rizwan, K., Zubair, M , Rasool, N. , Riaz, M., Zia-Ul-Haq, M. and de Feo, V., “Phytochemical and Biological Studies of Agave attenuata”, International Journal of Molecular Sciences, 13, 6440-6451, 2012.
  • [25] Gumgumjee, N.M. and Hajar, S.A. “Antibacterial activities and GC-MS analysis of phytocomponents of Ehretia abyssinica R.Br. ex fresen” International Journal of Applied Biology and Pharmaceutical Technology,6(2): 236-241, 2015.
  • [26] Habib, R. , Karim M. R., “Antitumour evaluation of di-(2-ethylhexyl) phthalate (DEHP) isolated from Calotropis gigantea L. flower“, Acta Pharmaceutica, 62(4):607-615, 2012.
  • [27] Drapeau, J., Verdier, M., Touraud, D., Kröckel, U., Geier, M., Rose, A., Kunz, W., “Effective insect repellent formulation in both surfactantless and classical microemulsions with a long-lasting protection for human beings”, Chemistry & biodiversity, 6(6):934-47, 2009.
  • [28] Accession adress: “http://fses.oregonstate.edu/”, accession date 01.12.2020.
  • [29] Öztürk, M., Duru, M. E., Aydoğmuş-Öztürk, F., Harmandar, M. , Mahlıçlı, M., Kolak, U. and Ulubelen, A., “GC-MS Analysis and Antimicrobial Activity of Essential Oil of Stachys cretica subsp. smyrnaea”, Natural Product Communications, 4 (1), 2009.
  • [30] Park, S,Y,, Park, S.J., Park, N.J., Joo, W.H., Lee, S.J., Choi, Y.W., “α-Iso-cubebene exerts neuroprotective effects in amyloid beta stimulated microglia activation”, Neuroscience Letters”, Oct 25;555:143-148. doi: 10.1016/j.neulet. 09.053, 2013.
  • [31] Kwon, B., Shin, H., Moon, H.B., Ji, K., Kim, K.T., “Effects of tris(2-butoxyethyl) phosphate exposure on endocrine systems and reproduction of zebrafish (Danio rerio)”, Environmental Pollution, 214:568-574, 2016.
  • [32] Sharififar, F., Mozaffarian, V., Moradkhani, S., (2007). “Comparison of antioxidant and free radical scavenging activities of the essential oils from flowers and fruits of Otostegia persica Boiss. Pakistan Journal of Biological Sciences, 10(21):3895-3899, 2007.
  • [33] Lin, X.H., Wu, Y.B., Lin, S. Zeng, J.W., Zeng, P.Y., Wu, J.Z. “Effects of volatile components and ethanolic extract from Eclipta prostrata on proliferation and differentiation of primary osteoblasts”, Molecules, 8;15(1):241-50, 2010.
  • [34]Sivasubramanian, R. and Brindha, P. “In- vitro cytotoxic, antioxidant and GC-MS studies on Centratherum punctatum cass.”, International Journal of Pharmacy and Pharmaceutical Sciences, 5( 3): 364-367, 2013.
  • [35] Islam, S., Firoz, M., “Triacontanol as a dynamic growth regulator for plants under diverse environmental conditions ”, Physiology and Molecular Biology of Plants, 26(5):871-883, 2020.
  • [36] Kuiate, J.R., Bessière, J.M., Zollo, P.H., Kuate, S.P., “Chemical composition and antidermatophytic properties of volatile fractions of hexanic extract from leaves of Cupressus lusitanica Mill. from Cameroon”, Journal of Ethnopharmacology, 16,103(2), 160-165, 2006.
  • [37] Kumar, S., Malhotra, R., Kumar, D., “Euphorbia hirta: Its chemistry, traditional and medicinal uses, and pharmacological activities”, Pharmacognosy Reviews, , 4(7), p58-61, 2010a.
  • [38] Jemia, M.B., Formisano, C., Bancheva, S., Bruno, M., Senatore, F., “Chemical composition of the essential oils of Centaurea formanekii and C. orphanidea ssp. thessala, growing wild in Greece”, Natural product communications, 7(8), 1083-1086, 2012.
  • [39] Begum, I., Faridha, R., Mohankumar, M., Jeevan, Ramani, K., “GC-MS Analysis of Bio-active Molecules Derived from Paracoccus pantotrophus FMR19 and the Antimicrobial Activity Against Bacterial Pathogens and MDROs”, Indian Journal of Microbiology,56(4):426-432, 2016.
  • [40] Zakariaa, M.B., Vijayasekarana, Ilhama, Z. and Muhamad, N.A., “Anti-Inflammatory Activity of Calophyllum inophyllum Fruits Extracts”. Procedia Chemistry, 13: 218-222, 2014. [41] Köse, Y.B., Iscan, G. and Demirci, B., “Antimicrobial Activity of the Essential Oils Obtained from Flowering Aerial Parts of Centaurea lycopifolia Boiss. et Kotschy and Centaurea cheirolopha (Fenzl) Wagenitz from Turkey” Journal of Essential Oil Bearing Plants, 19 (3): 762 -768, 2016.
  • [42] Yamuna, P., Abirami, P., Vijayashalini, P. and Sharmila, M., “GC-MS analysis of bioactive compounds in the entire plant parts of ethanolic extract of Gomphrena decumbens Jacq.”, Journal of Medicinal Plants Studies, 5(3) 31-37, 2017.
  • [43] Öğütçü, H., Sökmen, A., Sökmen, M., Polissiou, M., Serkedjieva, J., Daferera, D., Şahin, F., Barış, Ö., Güllüce, M. “Bioactivities of the Various Extracts and Essential Oils of Salvia limbata C.A.Mey. and Salvia sclarea L.” Turkish Journal of Biology, 32, 181-192, 2008.
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There are 47 citations in total.

Details

Primary Language English
Subjects Structural Biology
Journal Section Article
Authors

Alevcan Kaplan 0000-0001-6738-7527

Umut Çelikoğlu 0000-0003-0995-8154

Publication Date December 29, 2020
Submission Date December 5, 2020
Acceptance Date December 29, 2020
Published in Issue Year 2020 Volume: 6 Issue: 2

Cite

IEEE A. Kaplan and U. Çelikoğlu, “EVALUATION OF PHYTOCHEMICAL CONSTITUENTS IN THE WHOLE PLANT PARTS OF HEXANE EXTRACT OF SOME TRADITIONAL MEDICINAL PLANTS BY GC-MS ANALYSIS”, MEJS, vol. 6, no. 2, pp. 57–67, 2020.

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