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EFFECT OF FUNCTIONAL FOOD COMPONENTS ON COGNITIVE FUNCTIONS

Year 2024, Volume: 8 Issue: 1, 1 - 15, 30.04.2024
https://doi.org/10.34084/bshr.1413281

Abstract

60% of the brain consists of fat and is a structure vulnerable to damage from free radicals formed as a result of oxidative stress at cellular level. Accumulation of free radicals can cause oxidation, disruption of DNA repair mechanisms; such cellular changes can cause neuronal dysfunction and damages in functional neuroplasticity. Nutrition is one of the primary factors affecting brain development, and continues to affect cell renewal throughout life. In this review, it is aimed to explain the effects of oxidative stress at molecular level and some nutritional components, bioactive substances in foods on brain cells and therefore cognitive functions. It has been determined in various studies that omega 3 fatty acids, vitamins, minerals, bioactive components such as choline, polyphenols and psychobiotics positively affect cognitive function by supporting cell repair against oxidative damage. In this review, prominent nutritional components, bioactive substances and their mechanisms are explained as much as possible.

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FONKSİYONEL GIDA BİLEŞENLERİNİN BİLİŞSEL FONKSİYONLAR ÜZERİNE MOLEKÜLER ETKİ MEKANİZMALARI

Year 2024, Volume: 8 Issue: 1, 1 - 15, 30.04.2024
https://doi.org/10.34084/bshr.1413281

Abstract

Beynin %60’ı yağdan oluşur ve hücre düzeyinde oksidatif stres sonucunda oluşan serbest radikallerin vereceği hasara açık bir yapıdır. Nöronlarda üretilen başlıca serbest radikaller, süperoksit ve nitrik oksittir. Serbest radikallerin birikimi DNA oksidasyonuna ve DNA onarım mekanizmalarının bozulmasına neden olabilir; bu gibi hücresel değişiklikler nöronal işlev bozukluğuna, işlevsel ve yapısal nöroplastisiteye zarar verebilmektedir. Erken beyin gelişimini etkileyen faktörlerin başında beslenme gelmekte ve beslenme şekli hayat boyu hücre yenileme ve onarımını etkilemeyi sürdürmektedir. Bu derlemede oksidatif stresin moleküler düzeyde hücreye etkilerinin açıklanması ve gıdalardaki bazı besin bileşenleriyle, biyoaktif maddelerin beyin hücrelerine ve dolayısıyla bilişsel fonksiyonlara etkilerinin açıklanması hedeflenmiştir. Omega 3 yağ asitlerinin, vitaminlerin ve minerallerin, kolin, polifenoller gibi biyoaktif bileşenlerle psikobiyotiklerin, oksidatif hasara karşı hücre onarımına destek vererek, bilişsel fonksiyonu olumlu etkilediği çeşitli araştırmalarda belirlenmiştir. Bu derlemede öne çıkan besin bileşenleriyle, biyoaktif maddeler ve etki mekanizmaları mümkün olabildiğince açıklanmıştır.

Project Number

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There are 162 citations in total.

Details

Primary Language Turkish
Subjects Food Nutritional Balance
Journal Section Review
Authors

Zeynep Seydim 0000-0002-1536-6545

Sinem Keles 0000-0003-1861-7116

Gülçin Şatır 0000-0003-1862-6434

Project Number ----
Early Pub Date May 19, 2024
Publication Date April 30, 2024
Submission Date January 3, 2024
Acceptance Date March 9, 2024
Published in Issue Year 2024 Volume: 8 Issue: 1

Cite

AMA Seydim Z, Keles S, Şatır G. FONKSİYONEL GIDA BİLEŞENLERİNİN BİLİŞSEL FONKSİYONLAR ÜZERİNE MOLEKÜLER ETKİ MEKANİZMALARI. J Biotechnol and Strategic Health Res. April 2024;8(1):1-15. doi:10.34084/bshr.1413281
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